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Peptide record

TPDB12111

Antibacterial Antifungal Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12111
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIFSKLAGKKIKNLLISGLKNIGKEVGMDVVRTGIDIAGCKIKGEC
Physicochemical Analysis
C213H373N59O60S3
QHPWY
GK
4816.84
10.11
9
4
18
+5
10.17
0.226
116.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.60
7
Residue Composition
number
2
A
1
R
2
N
2
D
2
C
2
E
0
Q
8
G
0
H
7
I
4
L
8
K
1
M
1
F
0
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 2 E: 2 Q: 0 G: 8 H: 0 I: 7 L: 4 K: 8 M: 1 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
46
C213H373N59O60S3
4816.84
10.11
+5
10.17
0.226
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

M. luteus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
wed broad activity against G+ and G- bacteria but poor hemolytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa,
Evidence 2 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

B. subtilis

Source & Reference

dbAMP

Other

G+ and G- bacteria but poor hemolytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

S. dysentariae

Source & Reference

dbAMP

Other

lytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml), K. pneumoniae (12.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP

Other

B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml), K. pneumoniae (12.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
6.3 µg/mL

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
wed broad activity against G+ and G- bacteria but poor hemolytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa,
Evidence 6 Activity

Activity

MIC
Antifungal
6.3 µg/mL

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

G+ and G- bacteria but poor hemolytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

S. dysentariae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lytic activity. active against M. luteus (MIC 6.3 ug/ml), B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml), K. pneumoniae (12.5 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP CAFPdb Antifungipept

Other

B. subtilis (MIC 6.3 ug/ml), G- S. dysentariae (MIC 12.5 ug/ml), E. coli, P. aeruginosa, S. typhimurium (MIC 25 ug/ml), K. pneumoniae (12.5 ug/ml).
Evidence 9 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of antimicrobial peptides from the skin of Rana esculenta inhabiting in Korea. | Mol Cells | 2004