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Peptide record

TPDB12098

Antibacterial Anticancer Antifungal standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12098
Antibacterial Anticancer Antifungal
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia dbACP dbAMP 3.0 Antifungipept
standard
No
A 45-aa standard-residue multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
CETPSKHFNGLCIRSSNCASVCHGEHFTDGRCQGVRRRCMCLKPC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C203H329N71O61S9
WY
C
5028.82
8.32
10
3
9
+4
2.50
-0.456
41.11
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
500
0.10
17
Residue Composition
number
1
A
5
R
2
N
1
D
8
C
2
E
1
Q
4
G
3
H
1
I
2
L
2
K
1
M
2
F
2
P
4
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 5 N: 2 D: 1 C: 8 E: 2 Q: 1 G: 4 H: 3 I: 1 L: 2 K: 2 M: 1 F: 2 P: 2 S: 4 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
45 reviewed residue count
C203H329N71O61S9 sequence-only estimate (linear, free termini)
5028.82 sequence-only estimate (linear, free termini)
8.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.50 sequence-only estimate (linear, free termini)
-0.456 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against S. aureus and E. coli. It inhibits breast cancer cells MCF-7 as well ( Guzmán-Rodríguez JJ et al., 2016 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against S. aureus and E. coli. It inhibits breast cancer cells MCF-7 as well ( Guzmán-Rodríguez JJ et al., 2016 ).