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Peptide record

TPDB12097

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12097
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK
Physicochemical Analysis
C221H380N76O56S6
DHMWY
RK
5190.28
10.86
14
2
11
+12
11.17
-0.636
60.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
375
7.23
12
Residue Composition
number
1
A
7
R
2
N
0
D
6
C
2
E
1
Q
5
G
0
H
2
I
4
L
7
K
0
M
3
F
1
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 7 N: 2 D: 0 C: 6 E: 2 Q: 1 G: 5 H: 0 I: 2 L: 4 K: 7 M: 0 F: 3 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
45
C221H380N76O56S6
5190.28
10.86
+12
11.17
-0.636
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram-positive bacteria S. aureus ATCC 12600, S. aureus ATCC 33593, S. epidermidis ATCC 14990, S. pyogenes ATCC 12344, E. faecalis ATCC 29212, E faecalis ATCC 51299 (anti-VRE) (MBC 1.2-2.4 uM), Gram-negative bacteria E. coli ATCC 11775, E. coli ATCC 25922, E. coli ESBL 4 (clinical isolate), S. enterica serovar Typhimurium ATCC 13311 (MBC 0.6-1.2 uM), P. aeruginosa ATCC 10145, P. aeruginosa Va 6201/2000 (multiresistant clinical isolate), and yeast C. albicans ATCC 24433 (MBC 1.2 uM). Like hBD-3, this peptide also displays chemotactic effects to cells expressing CCR2 or CCR6 receptors. Activation of this path could promote cell growth, including tumor cells Röhrl J, et al., 2012 . It has anticancer effect on lung cancer cells ( Hanaoka Y et al., 2016 Phan et al., 2016 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram-positive bacteria S. aureus ATCC 12600, S. aureus ATCC 33593, S. epidermidis ATCC 14990, S. pyogenes ATCC 12344, E. faecalis ATCC 29212, E faecalis ATCC 51299 (anti-VRE) (MBC 1.2-2.4 uM), Gram-negative bacteria E. coli ATCC 11775, E. coli ATCC 25922, E. coli ESBL 4 (clinical isolate), S. enterica serovar Typhimurium ATCC 13311 (MBC 0.6-1.2 uM), P. aeruginosa ATCC 10145, P. aeruginosa Va 6201/2000 (multiresistant clinical isolate), and yeast C. albicans ATCC 24433 (MBC 1.2 uM). Like hBD-3, this peptide also displays chemotactic effects to cells expressing CCR2 or CCR6 receptors. Activation of this path could promote cell growth, including tumor cells Röhrl J, et al., 2012 . It has anticancer effect on lung cancer cells ( Hanaoka Y et al., 2016 Phan et al., 2016 ).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against Gram-positive bacteria S. aureus ATCC 12600, S. aureus ATCC 33593, S. epidermidis ATCC 14990, S. pyogenes ATCC 12344, E. faecalis ATCC 29212, E faecalis ATCC 51299 (anti-VRE) (MBC 1.2-2.4 uM), Gram-negative bacteria E. coli ATCC 11775, E. coli ATCC 25922, E. coli ESBL 4 (clinical isolate), S. enterica serovar Typhimurium ATCC 13311 (MBC 0.6-1.2 uM), P. aeruginosa ATCC 10145, P. aeruginosa Va 6201/2000 (multiresistant clinical isolate), and yeast C. albicans ATCC 24433 (MBC 1.2 uM). Like hBD-3, this peptide also displays chemotactic effects to cells expressing CCR2 or CCR6 receptors. Activation of this path could promote cell growth, including tumor cells Röhrl J, et al., 2012 . It has anticancer effect on lung cancer cells ( Hanaoka Y et al., 2016 Phan et al., 2016 ).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Active against Gram-positive bacteria S. aureus ATCC 12600, S. aureus ATCC 33593, S. epidermidis ATCC 14990, S. pyogenes ATCC 12344, E. faecalis ATCC 29212, E faecalis ATCC 51299 (anti-VRE) (MBC 1.2-2.4 uM), Gram-negative bacteria E. coli ATCC 11775, E. coli ATCC 25922, E. coli ESBL 4 (clinical isolate), S. enterica serovar Typhimurium ATCC 13311 (MBC 0.6-1.2 uM), P. aeruginosa ATCC 10145, P. aeruginosa Va 6201/2000 (multiresistant clinical isolate), and yeast C. albicans ATCC 24433 (MBC 1.2 uM). Like hBD-3, this peptide also displays chemotactic effects to cells expressing CCR2 or CCR6 receptors. Activation of this path could promote cell growth, including tumor cells Röhrl J, et al., 2012 . It has anticancer effect on lung cancer cells ( Hanaoka Y et al., 2016 Phan et al., 2016 ).