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Peptide record

TPDB12094

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12094
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RPPQFTRAQWFAIQHISLNPPRSTIAMRAINNYRWRSKNQNTFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C246H382N80O62S1
DCEGV
R
5484.30
12.80
9
0
17
+8
3.01
-0.911
60.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
2.28
16
Residue Composition
number
4
A
7
R
5
N
0
D
0
C
0
E
4
Q
0
G
1
H
4
I
2
L
1
K
1
M
3
F
4
P
3
S
3
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 7 N: 5 D: 0 C: 0 E: 0 Q: 4 G: 0 H: 1 I: 4 L: 2 K: 1 M: 1 F: 3 P: 4 S: 3 T: 3 W: 2 Y: 1 V: 0
Chemical Descriptors
45 reviewed residue count
C246H382N80O62S1 sequence-only estimate (linear, free termini)
5484.30 sequence-only estimate (linear, free termini)
12.80 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
3.01 sequence-only estimate (linear, free termini)
-0.911 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
11.7±0.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.7±0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization. | J Med Chem | 2011
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis