TPDB

3D PDB MODEL

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TPDB ID TPDB12093

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 45-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

FIFHIIKGLFHAGKMIHGLVTRRRHGVEELQDLDQRAFEREKAFA

FASTA

>TPDB12093|Antibacterial;Anticancer;Toxicity|length=45
FIFHIIKGLFHAGKMIHGLVTRRRHGVEELQDLDQRAFEREKAFA

Formula C242H379N73O61S1

Absent Amino Acids NCPSWY

Common Amino Acids RF

Mass 5319.18

PI 10.30

Basic Residues 12

Acidic Residues 6

Hydrophobic Residues 20

Net Charge +2

Boman Index 12.84

Hydrophobicity -0.280

Aliphatic Index 91.11

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

4

A

5

R

0

N

2

D

0

C

4

E

2

Q

4

G

4

H

4

I

4

L

3

K

1

M

5

F

0

P

0

S

1

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 4 R: 5 N: 0 D: 2 C: 0 E: 4 Q: 2 G: 4 H: 4 I: 4 L: 4 K: 3 M: 1 F: 5 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2

Length

45

Formula

C242H379N73O61S1

Mass

5319.18

PI

10.30

Net Charge

+2

Boman Index

12.84

Hydrophobicity

-0.280

Evidence 1 Activity

Activity

Activity Endpoint 25% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

25% Hemolysis | 20 | µM | target cell: Fish erythrocytes

Target

Target Cell Fish erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 2 Activity

Activity

Activity Endpoint 47% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

47% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 3 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Fish erythrocytes:25% Hemolysis=20µM Rabbit erythrocytes:47% Hemolysis=20µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Probiotics Antimicrob Proteins. 2019 Jun 11(2):667-675.