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Peptide record

TPDB12086

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12086
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KPPQFTWAQWFETQHINMTSQQSTNAMQVINNYQRRSKNQNTFLL
Physicochemical Analysis
C241H365N71O71S2
DCG
Q
5457.10
10.71
5
1
15
+3
5.23
-1.069
45.56
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
12490
228.88
23
Residue Composition
number
2
A
2
R
6
N
0
D
0
C
1
E
8
Q
0
G
1
H
2
I
2
L
2
K
2
M
3
F
2
P
3
S
5
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 6 D: 0 C: 0 E: 1 Q: 8 G: 0 H: 1 I: 2 L: 2 K: 2 M: 2 F: 3 P: 2 S: 3 T: 5 W: 2 Y: 1 V: 1
Chemical Descriptors
45
C241H365N71O71S2
5457.10
10.71
+3
5.23
-1.069
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis