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Peptide record

TPDB12084

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12084
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KPKDMTSSQWFKTQHVQPSPQASNSAMSIINKYTERSKDLNTFLH
Physicochemical Analysis
C228H357N65O71S2
CG
S
5208.86
10.20
8
3
13
+3
11.04
-1.044
45.56
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
134.19
19
Residue Composition
number
2
A
1
R
3
N
2
D
0
C
1
E
4
Q
0
G
2
H
2
I
2
L
5
K
2
M
2
F
3
P
7
S
4
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 3 D: 2 C: 0 E: 1 Q: 4 G: 0 H: 2 I: 2 L: 2 K: 5 M: 2 F: 2 P: 3 S: 7 T: 4 W: 1 Y: 1 V: 1
Chemical Descriptors
45
C228H357N65O71S2
5208.86
10.20
+3
11.04
-1.044
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
15.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 15.1 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis