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Peptide record

TPDB12082

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12082
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
WPKRLTKAHWFEIQHIQPSPLQSNRAMSGINNYTQHSKHQNTFLH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C243H365N75O65S1
DCV
QH
5409.09
10.89
10
1
14
+4
2.34
-1.096
56.44
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
12490
2.31
17
Residue Composition
number
2
A
2
R
4
N
0
D
0
C
1
E
5
Q
1
G
5
H
3
I
3
L
3
K
1
M
2
F
3
P
4
S
3
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 4 D: 0 C: 0 E: 1 Q: 5 G: 1 H: 5 I: 3 L: 3 K: 3 M: 1 F: 2 P: 3 S: 4 T: 3 W: 2 Y: 1 V: 0
Chemical Descriptors
45 reviewed residue count
C243H365N75O65S1 sequence-only estimate (linear, free termini)
5409.09 sequence-only estimate (linear, free termini)
10.89 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.34 sequence-only estimate (linear, free termini)
-1.096 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
17.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 17.4 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis