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Peptide record

TPDB12082

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12082
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
WPKRLTKAHWFEIQHIQPSPLQSNRAMSGINNYTQHSKHQNTFLH
Physicochemical Analysis
C243H365N75O65S1
DCV
QH
5409.09
10.89
10
1
14
+4
8.21
-1.096
56.44
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
12490
230.91
17
Residue Composition
number
2
A
2
R
4
N
0
D
0
C
1
E
5
Q
1
G
5
H
3
I
3
L
3
K
1
M
2
F
3
P
4
S
3
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 4 D: 0 C: 0 E: 1 Q: 5 G: 1 H: 5 I: 3 L: 3 K: 3 M: 1 F: 2 P: 3 S: 4 T: 3 W: 2 Y: 1 V: 0
Chemical Descriptors
45
C243H365N75O65S1
5409.09
10.89
+4
8.21
-1.096
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
17.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 17.4 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis