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Peptide record

TPDB12080

Antibacterial Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12080
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLH
Physicochemical Analysis
C243H365N75O63S3
DV
QH
5441.22
10.07
10
1
14
+4
7.47
-0.949
56.44
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
12615
231.84
17
Residue Composition
number
2
A
2
R
4
N
0
D
2
C
1
E
5
Q
1
G
5
H
3
I
3
L
3
K
1
M
2
F
3
P
2
S
3
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 4 D: 0 C: 2 E: 1 Q: 5 G: 1 H: 5 I: 3 L: 3 K: 3 M: 1 F: 2 P: 3 S: 2 T: 3 W: 2 Y: 1 V: 0
Chemical Descriptors
45
C243H365N75O63S3
5441.22
10.07
+4
7.47
-0.949
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>20 µM
Hemolytic Cytotoxic
50% Hemolysis | >20 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. | Int J Mol Sci | 2016