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Peptide record

TPDB12078

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12078
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 45-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KPKGMTSSQWFKIQHMQPSPQASNSAMKNINKHTKRSKDLNTFLH
Physicochemical Analysis
C227H364N70O65S3
CEYV
K
5210.00
11.26
11
1
12
+7
11.53
-1.209
39.11
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
105.57
17
Residue Composition
number
2
A
1
R
4
N
1
D
0
C
0
E
4
Q
1
G
3
H
2
I
2
L
7
K
3
M
2
F
3
P
6
S
3
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 4 D: 1 C: 0 E: 0 Q: 4 G: 1 H: 3 I: 2 L: 2 K: 7 M: 3 F: 2 P: 3 S: 6 T: 3 W: 1 Y: 0 V: 0
Chemical Descriptors
45
C227H364N70O65S3
5210.00
11.26
+7
11.53
-1.209
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
10.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 10.4 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis