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Peptide record

TPDB12075

Antibacterial Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB12075
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GIINTLQKYYSRVRGGRSAVLSSLPKEEQIGKSSTRGRKSSRRKK
Physicochemical Analysis
C216H377N75O65
DCHMFW
S
5064.83
12.06
13
2
11
+11
14.53
-1.140
67.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
58.84
15
Residue Composition
number
1
A
7
R
1
N
0
D
0
C
2
E
2
Q
5
G
0
H
3
I
3
L
6
K
0
M
0
F
1
P
8
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 7 N: 1 D: 0 C: 0 E: 2 Q: 2 G: 5 H: 0 I: 3 L: 3 K: 6 M: 0 F: 0 P: 1 S: 8 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
45
C216H377N75O65
5064.83
12.06
+11
14.53
-1.140
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

LD90 (lethal dose killing > 90%): active against E. coli WBB01 or ATCC 11775 (LD90 0.2-0.39 ug/ml), S. enterica sv Minnesota strain R595 or R60 or PXG1 (L90 0.1-0.2 ug/ml), P. mirabilis R45 (LD90 0.2 ug/ml), B. cepacia WaaC::kann (LD90 3.1 ug/ml), B.cepacia ATCC 25416 (LD90 > 100 ug/ml), and P. aeruginosa ATCC 1014 (LD90 0.2 ug/ml). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Linear analogues of human beta-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells. | Chembiochem | 2008
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
150 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 150 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria. | Biochim Biophys Acta | 2020