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Peptide record

TPDB12070

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB12070
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 AI4AVP APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFRHLFRGAKAIFRGARQGWRAHKVVSRYRNRDVPETDNNQEEP
Physicochemical Analysis
C235H360N80O63
CM
R
5313.94
11.64
12
5
15
+5
13.87
-1.227
46.59
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
131.54
8
Residue Composition
number
4
A
8
R
3
N
2
D
0
C
3
E
2
Q
3
G
2
H
1
I
1
L
2
K
0
M
4
F
2
P
1
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 8 N: 3 D: 2 C: 0 E: 3 Q: 2 G: 3 H: 2 I: 1 L: 1 K: 2 M: 0 F: 4 P: 2 S: 1 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
44
C235H360N80O63
5313.94
11.64
+5
13.87
-1.227
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

S. iniae

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
d human pathogens, including multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
9.41 µM

Target

L. garvieae

Source & Reference

dbAMP DRAMP

Other

uding multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis
Evidence 3 Activity

Activity

MIC
Antibacterial
1.18 µM

Target

V. anguillarum

Source & Reference

dbAMP DRAMP

Other

bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
1.18 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

IC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its
Evidence 5 Activity

Activity

MIC
Antibacterial
1.18 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

(MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal con
Evidence 6 Activity

Activity

MIC
Antibacterial
1.18-2.35 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP

Other

cida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC10
Evidence 7 Activity

Activity

MIC
Antibacterial
9.41 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

s E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC100 1.18 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
4.7 µM

Target

S. iniae

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
d human pathogens, including multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
9.41 µM

Target

L. garvieae

Source & Reference

dbAMP DRAMP Antifungipept

Other

uding multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis
Evidence 10 Activity

Activity

MIC
Antifungal
1.18 µM

Target

V. anguillarum

Source & Reference

dbAMP DRAMP Antifungipept

Other

bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
1.18 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP Antifungipept

Other

IC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its
Evidence 12 Activity

Activity

MIC
Antifungal
1.18 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal con
Evidence 13 Activity

Activity

MIC
Antifungal
1.18-2.35 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP Antifungipept

Other

cida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC10
Evidence 14 Activity

Activity

MIC
Antifungal
9.41 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

s E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC100 1.18 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
4.7 µM

Target

S. iniae

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
d human pathogens, including multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM),
Evidence 16 Activity

Activity

MIC
Antiparasitic
9.41 µM

Target

L. garvieae

Source & Reference

dbAMP 3.0 DRAMP

Other

uding multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis
Evidence 17 Activity

Activity

MIC
Antiparasitic
1.18 µM

Target

V. anguillarum

Source & Reference

dbAMP 3.0 DRAMP

Other

bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC
Evidence 18 Activity

Activity

MIC
Antiparasitic
1.18 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its
Evidence 19 Activity

Activity

MIC
Antiparasitic
1.18 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal con
Evidence 20 Activity

Activity

MIC
Antiparasitic
1.18-2.35 µM

Target

S. flexneri

Source & Reference

dbAMP 3.0 DRAMP

Other

cida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC10
Evidence 21 Activity

Activity

MIC
Antiparasitic
9.41 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

s E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC100 1.18 uM).
Evidence 22 Activity

Activity

MIC
Antiviral
4.7 µM

Target

S. iniae

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
d human pathogens, including multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM),
Evidence 23 Activity

Activity

MIC
Antiviral
9.41 µM

Target

L. garvieae

Source & Reference

dbAMP 3.0 DRAMP

Other

uding multi-drug resistant bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis
Evidence 24 Activity

Activity

MIC
Antiviral
1.18 µM

Target

V. anguillarum

Source & Reference

dbAMP 3.0 DRAMP

Other

bacteria. Active against fish pathogens S. iniae (MIC 4.7 uM), L. garvieae (MIC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC
Evidence 25 Activity

Activity

MIC
Antiviral
1.18 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

IC 9.41 uM), V. anguillarum (MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its
Evidence 26 Activity

Activity

MIC
Antiviral
1.18 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

(MIC 1.18 uM), A-salmonicida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal con
Evidence 27 Activity

Activity

MIC
Antiviral
1.18-2.35 µM

Target

S. flexneri

Source & Reference

dbAMP 3.0 DRAMP

Other

cida (MIC >37.54 uM), human pathogens E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC10
Evidence 28 Activity

Activity

MIC
Antiviral
9.41 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

s E. faecalis (MIC 1.18 uM), S. aureus (MIC 1.18 uM), S. flexneri (MIC 1.18-2.35 uM), and E. coli (MIC 9.41 uM). Its minimum parasiticidal concentrations (PCmin 0.59 uM PC100 1.18 uM).
Evidence 29 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of piscidin 4, a piscine antimicrobial peptide. | Biochemistry | 2011
Evidence 30 Activity

Activity

18% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 100 | µg/mL | target cell: Hybrid striped bass erythrocytes

Target

Hybrid striped bass erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of piscidin 4, a piscine antimicrobial peptide. | Biochemistry | 2011
Evidence 31 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.