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Peptide record

TPDB12067

Antibacterial Anticancer Antifungal Antiparasitic standard

44 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12067

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE

FASTA

>TPDB12067|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=44
DKLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFWNVNCWCEE

Formula C210H308N62O66S6

Absent Amino Acids QMP

Common Amino Acids CG

Mass 4949.49

PI 6.76

Basic Residues 6

Acidic Residues 5

Hydrophobic Residues 12

Net Charge -0

Boman Index 5.41

Hydrophobicity -0.655

Aliphatic Index 35.45

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 19855

Absorbance 280nm 401.15

Polar Residues 17

number

Amino Acid Distribution

A: 2 R: 2 N: 4 D: 2 C: 6 E: 3 Q: 0 G: 6 H: 1 I: 1 L: 1 K: 3 M: 0 F: 1 P: 0 S: 3 T: 2 W: 3 Y: 2 V: 2

Length

Formula

C210H308N62O66S6

Mass

4949.49

6.76

Net Charge

-0

Boman Index

5.41

Hydrophobicity

-0.655

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.9 µM

Target

Target Organism S. lutea

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM)

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.9 µM

Target

Target Organism P. stipitis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9 uM), C. fructus (MIC 1.4-2.9 u

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism C. fructus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

arxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harz

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.9 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updat

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.4-2.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.9 µM

Target

Target Organism S. lutea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM)

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.9 µM

Target

Target Organism P. stipitis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism C. fructus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.9 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.4-2.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.9 µM

Target

Target Organism S. lutea

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM)

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.9 µM

Target

Target Organism P. stipitis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram+ S. lutea (MIC 1.9 uM), fungi P. pastoris (MIC 1.4-2.9 uM), P. stipitis (MIC 2.9 uM), Z. marxianus (MIC 1.4-2.9 uM), P. tannophilus (MIC 1.4-2.9 uM), C. albicans (MIC 1.4-2.9

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism C. fructus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.9 µM

Target

Target Organism C. wickerhamii

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism A. niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

-2.9 uM), C. fructus (MIC 1.4-2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.4-2.9 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source DRAMP

Other

Evidence Text

2.9 uM), C. wickerhamii (MIC 2.9 uM), and filamentous fungi A. niger (MIC 1.4-2.9 uM) and T. harzianum (MIC 1.4-2.9 uM). Updated 3/2020 11/2025