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Peptide record

TPDB12062

Antibacterial Antifungal standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB12062
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 44-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GGKCTVDWGGQGGGRRLPSPLFCCYKPTRICYLNQETCETETCP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C205H319N59O64S6
AHM
G
4826.50
7.62
5
4
9
+1
1.73
-0.566
42.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
1.83
17
Residue Composition
number
0
A
3
R
1
N
1
D
6
C
3
E
2
Q
7
G
0
H
1
I
3
L
2
K
0
M
1
F
4
P
1
S
5
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 6 E: 3 Q: 2 G: 7 H: 0 I: 1 L: 3 K: 2 M: 0 F: 1 P: 4 S: 1 T: 5 W: 1 Y: 2 V: 1
Chemical Descriptors
44 reviewed residue count
C205H319N59O64S6 sequence-only estimate (linear, free termini)
4826.50 sequence-only estimate (linear, free termini)
7.62 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.73 sequence-only estimate (linear, free termini)
-0.566 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
Antibacterial
5.2 µM

Target

B. cinerea

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ampestris, Gram+ C. michiganense, and B. subtilis (0.8-1.3 cm). Also active against fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no
Evidence 2 Activity

Activity

IC50
Antibacterial
2.6 µM

Target

A. niger

Source & Reference

dbAMP DRAMP

Other

anense, and B. subtilis (0.8-1.3 cm). Also active against fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no activity below 10 uM ag
Evidence 3 Activity

Activity

IC50
Antibacterial
2.6 µM

Target

P. debaryanum

Source & Reference

dbAMP DRAMP

Other

inst fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no activity below 10 uM against F-oxysporum and F-graminearum (IC50 >10 uM).
Evidence 4 Activity

Activity

IC50
Antifungal
5.2 µM

Target

B. cinerea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ampestris, Gram+ C. michiganense, and B. subtilis (0.8-1.3 cm). Also active against fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no
Evidence 5 Activity

Activity

IC50
Antifungal
2.6 µM

Target

A. niger

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

anense, and B. subtilis (0.8-1.3 cm). Also active against fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no activity below 10 uM ag
Evidence 6 Activity

Activity

IC50
Antifungal
2.6 µM

Target

P. debaryanum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst fungi B. cinerea (IC50 5.2 uM), A. niger (IC50 2.6 uM), B. sorokiniana IC50 5.2 uM), P. debaryanum (IC50 2.6 uM), but no activity below 10 uM against F-oxysporum and F-graminearum (IC50 >10 uM).