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Peptide record

TPDB12057

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB12057
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VTCDLLSAEAKGVKVNHAACAAHCLLKRKRGGYCNKRRICVCRN
Physicochemical Analysis
C201H347N71O55S6
QMFPW
AC
4830.77
9.93
12
2
16
+8
10.06
-0.173
84.32
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1865
38.61
12
Residue Composition
number
6
A
5
R
3
N
1
D
6
C
1
E
0
Q
3
G
2
H
1
I
4
L
5
K
0
M
0
F
0
P
1
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 6 R: 5 N: 3 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 2 I: 1 L: 4 K: 5 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
44
C201H347N71O55S6
4830.77
9.93
+8
10.06
-0.173
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
13.2 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and
Evidence 2 Activity

Activity

MIC
Antibacterial
6 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 u
Evidence 3 Activity

Activity

MIC
Antibacterial
4.6 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

ctive against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non
Evidence 4 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 5 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP

Other

, B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 6 Activity

Activity

MIC
Antifungal
13.2 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and
Evidence 7 Activity

Activity

MIC
Antifungal
6 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 u
Evidence 8 Activity

Activity

MIC
Antifungal
4.6 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ctive against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non
Evidence 9 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 10 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

K.pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 11 Activity

Activity

MIC
Antiparasitic
13.2 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and
Evidence 12 Activity

Activity

MIC
Antiparasitic
6 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 u
Evidence 13 Activity

Activity

MIC
Antiparasitic
4.6 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

ctive against E-coli (MIC >75 ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non
Evidence 14 Activity

Activity

MIC
Antiparasitic
>200 µg/mL

Target

P.aeruginosa

Source & Reference

DRAMP

Other

ug/ml), S. aureus (MIC 13.2 ug/ml), B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 15 Activity

Activity

MIC
Antiparasitic
>200 µg/mL

Target

K.pneumoniae

Source & Reference

DRAMP

Other

, B. subtilis (MIC 6 uM), C. albicans (MIC 4.6 ug/ml), P.aeruginosa (MIC >200 ug/ml), and K.pneumoniae (MIC >200 ug/ml). In vitro toxicity: non-hemo.lytic till 200 ug/ml.
Evidence 16 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification and screening of potent antimicrobial peptides in arthropod genomes. | Peptides | 2018
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus. | PLoS One | 2015
Evidence 18 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29501691] 0% haemolysis at 10 µg/ml, 0% haemolysis at 25 µg/ml, 0% haemolysis at 50 µg/ml, 0% haemolysis at 100 µg/ml, 0% haemolysis at 200 µg/ml against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2018 May 103:26-30. doi: 10.1016/j.peptides.2018.01.017.