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Peptide record

TPDB12049

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB12049
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS
Physicochemical Analysis
C220H357N59O63
RCQHMFY
K
4836.61
10.32
8
4
18
+4
9.40
-0.518
86.59
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
341.15
10
Residue Composition
number
6
A
0
R
4
N
1
D
0
C
3
E
0
Q
2
G
0
H
2
I
4
L
8
K
0
M
0
F
2
P
3
S
3
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 0 N: 4 D: 1 C: 0 E: 3 Q: 0 G: 2 H: 0 I: 2 L: 4 K: 8 M: 0 F: 0 P: 2 S: 3 T: 3 W: 3 Y: 0 V: 3
Chemical Descriptors
44
C220H357N59O63
4836.61
10.32
+4
9.40
-0.518
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
10 30 %
[Ref.12354111]10% hemolytic activity at 10 µM, 30% hemolytic activity at 100 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Eur J Biochem. 2002 Oct 269(19):4799-4810.##Toxicon. 2002 Dec 40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7 311(1):90-97.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
ntibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. | Eur J Biochem | 2002
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12354111]10% hemolytic activity at 10 µM, 30% hemolytic activity at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2002 Oct 269(19):4799-4810.##Toxicon. 2002 Dec 40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7 311(1):90-97.
Evidence 4 Hemolysis

Activity

10 30 %
% Hemolysis
[Ref.12354111]10% hemolytic activity at 10 µM, 30% hemolytic activity at 100 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Eur J Biochem. 2002 Oct 269(19):4799-4810.##Toxicon. 2002 Dec 40(12):1679-1683.##iochem Biophys Res Commun. 2003 Nov 7 311(1):90-97.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.