Back to search

Peptide record

TPDB12048

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

44 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12048

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb DRAMP dbAMP i2APP dbAMP 3.0

Sequence_Type

standard

Has_Modification No

Description A 44-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Sequence

DCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC

FASTA

>TPDB12048|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=44
DCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC

Formula C199H312N64O65S8

Absent Amino Acids QIMF

Common Amino Acids C

Mass 4897.54

PI 7.50

Basic Residues 8

Acidic Residues 6

Hydrophobic Residues 8

Net Charge +1

Boman Index 12.16

Hydrophobicity -0.741

Aliphatic Index 33.18

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 12990

Absorbance 280nm 265.24

Polar Residues 16

number

Amino Acid Distribution

A: 1 R: 4 N: 1 D: 2 C: 8 E: 4 Q: 0 G: 5 H: 1 I: 0 L: 2 K: 3 M: 0 F: 0 P: 2 S: 5 T: 1 W: 2 Y: 1 V: 2

Length

Formula

C199H312N64O65S8

Mass

4897.54

7.50

Net Charge

Boman Index

12.16

Hydrophobicity

-0.741

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism A. ustus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). How

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ve against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). However, it is not active

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). However, it is not active against tested Gram-positive

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism A. ustus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). How

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism A. ustus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). How

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism A. fumigatus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism A. ustus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Only active against filamentous fungi, including A. fumigatus (MIC 6.25 uM), A. ustus (MIC 25 uM), F. solani (MIC 25 uM), F. oxysporum (MIC 6.25 uM) (Data from Simon A et al., 2008 ). How

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text