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Peptide record

TPDB12031

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

43 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12031

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb DRAMP

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

DTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE

FASTA

>TPDB12031|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=43
DTLIGSCVWGATNYTSDCNAECKRRGYKGGHCGSFLNVNCWCE

Formula C198H297N59O64S6

Absent Amino Acids QMP

Common Amino Acids CG

Mass 4720.25

PI 6.76

Basic Residues 5

Acidic Residues 4

Hydrophobic Residues 12

Net Charge -0

Boman Index 3.83

Hydrophobicity -0.405

Aliphatic Index 45.35

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 14355

Absorbance 280nm 304.12

Polar Residues 18

number

Amino Acid Distribution

A: 2 R: 2 N: 4 D: 2 C: 6 E: 2 Q: 0 G: 6 H: 1 I: 1 L: 2 K: 2 M: 0 F: 1 P: 0 S: 3 T: 3 W: 2 Y: 2 V: 2

Length

Formula

C198H297N59O64S6

Mass

4720.25

6.76

Net Charge

-0

Boman Index

3.83

Hydrophobicity

-0.405

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.5-16.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.2-8.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 u

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.2-8.5 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 uM), Filamentous fungi F. oxysporu

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.2-8.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

storis (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.2-8.5 µM

Target

Target Organism C. fructus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

arxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harz

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.5-16.9 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytryns

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.1-2.1 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

2-8.5 uM), C. fructus (MIC 4.2-8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytrynska et al. (2007) . Updated

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.1-4.2 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytrynska et al. (2007) . Updated 3/2020 8/2025 11/2025

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.5-16.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.2-8.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 u

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.2-8.5 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.2-8.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.2-8.5 µM

Target

Target Organism C. fructus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.5-16.9 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.1-2.1 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.1-4.2 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytrynska et al. (2007) . Updated 3/2020 8/2025 11/2025

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.5-16.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.2-8.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 u

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.2-8.5 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.2-8.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.2-8.5 µM

Target

Target Organism C. fructus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.5-16.9 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.1-2.1 µM

Target

Target Organism A. niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.1-4.2 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source DRAMP

Other

Evidence Text

8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytrynska et al. (2007) . Updated 3/2020 8/2025 11/2025

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8.5-16.9 µM

Target

Target Organism P. pastoris

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.2-8.5 µM

Target

Target Organism Z. marxianus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Yeast and yeast-like fungi P. pastoris (MIC 8.5-16.9 uM), Z. marxianus (MIC 4.2-8.5 uM), P. tannophilus (MIC 4.2-8.5 uM), C. albicans (MIC 4.2-8.5 uM), C. fructus (MIC 4.2-8.5 u

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.2-8.5 µM

Target

Target Organism P. tannophilus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.2-8.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.2-8.5 µM

Target

Target Organism C. fructus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8.5-16.9 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.1-2.1 µM

Target

Target Organism A. niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.1-4.2 µM

Target

Target Organism T. harzianum

Source & Reference

Database Source DRAMP

Other

Evidence Text

8.5 uM), Filamentous fungi F. oxysporum (MIC 8.5-16.9 uM), A. niger (MIC 1.1-2.1 uM), and T. harzianum (MIC 2.1-4.2 uM). Activity data from Cytrynska et al. (2007) . Updated 3/2020 8/2025 11/2025