TPDB

3D PDB MODEL

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TPDB ID TPDB12029

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 iACP-DRLF Antifp Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Sequence

RFRPPIRRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP

FASTA

>TPDB12029|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=43
RFRPPIRRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP

Formula C251H384N76O44

Absent Amino Acids ANDCEQHLKMSTWY

Common Amino Acids P

Mass 5170.29

PI 13.40

Basic Residues 11

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +11

Boman Index 9.97

Hydrophobicity -0.998

Aliphatic Index 43.02

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

11

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

4

I

0

L

0

K

0

M

6

F

20

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 0 K: 0 M: 0 F: 6 P: 20 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

43

Formula

C251H384N76O44

Mass

5170.29

PI

13.40

Net Charge

+11

Boman Index

9.97

Hydrophobicity

-0.998

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus 1056 MRSA

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism Candida albicans 3153A

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus 1056 MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism Candida albicans 3153A

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus 1056 MRSA

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism Candida albicans 3153A

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 4 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 10 ug/ml).