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Peptide record

TPDB12016

Antibacterial Anticancer Antifungal Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB12016
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb
standard
No
A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPS
Physicochemical Analysis
C214H339N57O59
RCHMY
AK
4654.39
10.41
7
3
19
+4
5.93
-0.316
81.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
354.50
9
Residue Composition
number
7
A
0
R
3
N
1
D
0
C
2
E
1
Q
3
G
0
H
3
I
2
L
7
K
0
M
1
F
2
P
3
S
2
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 7 R: 0 N: 3 D: 1 C: 0 E: 2 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 7 M: 0 F: 1 P: 2 S: 3 T: 2 W: 3 Y: 0 V: 3
Chemical Descriptors
43
C214H339N57O59
4654.39
10.41
+4
5.93
-0.316
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

B. subtilis NCIMB 8024

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC
Evidence 2 Activity

Activity

MIC
Antibacterial
32-64 µg/mL

Target

Staphylococcus aureus SH100

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
64-128 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

idis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

B. subtilis NCIMB 8024

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC
Evidence 5 Activity

Activity

MIC
Antifungal
32-64 µg/mL

Target

Staphylococcus aureus SH100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
64-128 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

idis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016