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Peptide record

TPDB12016

Antibacterial Anticancer Antifungal Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB12016
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb
standard
No
A 43-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVWDWIKKTAGKIWNSEPVKALKSQALNAAKNFVAEKIGATPS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C214H339N57O59
RCHMY
AK
4654.39
10.41
7
3
19
+4
0.93
-0.316
81.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
3.55
9
Residue Composition
number
7
A
0
R
3
N
1
D
0
C
2
E
1
Q
3
G
0
H
3
I
2
L
7
K
0
M
1
F
2
P
3
S
2
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 7 R: 0 N: 3 D: 1 C: 0 E: 2 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 7 M: 0 F: 1 P: 2 S: 3 T: 2 W: 3 Y: 0 V: 3
Chemical Descriptors
43 reviewed residue count
C214H339N57O59 sequence-only estimate (linear, free termini)
4654.39 sequence-only estimate (linear, free termini)
10.41 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.93 sequence-only estimate (linear, free termini)
-0.316 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

B. subtilis NCIMB 8024

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC
Evidence 2 Activity

Activity

MIC
Antibacterial
32-64 µg/mL

Target

Staphylococcus aureus SH100

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
64-128 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

idis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

B. subtilis NCIMB 8024

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC
Evidence 5 Activity

Activity

MIC
Antifungal
32-64 µg/mL

Target

Staphylococcus aureus SH100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis NCIMB 8024 (MIC 4 ug/ml), S. epidermidis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
64-128 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

idis sp., S. aureus SH100 (MIC 32-64 ug/ml), E. coli JM109, K. pneumoniae NCTC 13439, and C. albicans (MIC 64-128 ug/ml).
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016