TPDB

3D PDB MODEL

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TPDB ID TPDB12010

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifp Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP

FASTA

>TPDB12010|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=43
RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP

Formula C252H376N74O45

Absent Amino Acids ADCEQHLKMSTWY

Common Amino Acids P

Mass 5162.23

PI 13.35

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +10

Boman Index 8.76

Hydrophobicity -1.014

Aliphatic Index 33.95

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

10

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

3

I

0

L

0

K

0

M

7

F

20

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 10 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 0 K: 0 M: 0 F: 7 P: 20 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

43

Formula

C252H376N74O45

Mass

5162.23

PI

13.35

Net Charge

+10

Boman Index

8.76

Hydrophobicity

-1.014

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5-3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

, L. monocytogenes EGDP (MIC < 2.5 ug/ml), P. aeruginosa (MIC < 2 ug/ml), S. typhimurium, C. albicans (MIC 1.5-3 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5-3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

, L. monocytogenes EGDP (MIC < 2.5 ug/ml), P. aeruginosa (MIC < 2 ug/ml), S. typhimurium, C. albicans (MIC 1.5-3 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5-3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

, L. monocytogenes EGDP (MIC < 2.5 ug/ml), P. aeruginosa (MIC < 2 ug/ml), S. typhimurium, C. albicans (MIC 1.5-3 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.5-3 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

, L. monocytogenes EGDP (MIC < 2.5 ug/ml), P. aeruginosa (MIC < 2 ug/ml), S. typhimurium, C. albicans (MIC 1.5-3 ug/ml).