TPDB

3D PDB MODEL

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TPDB ID TPDB12006

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

MWGRILGTVAKYGPKAVSWAWQHKWELINMGDLAFRYIQRIWG

FASTA

>TPDB12006|Antibacterial;Antifungal|length=43
MWGRILGTVAKYGPKAVSWAWQHKWELINMGDLAFRYIQRIWG

Formula C243H359N65O55S2

Absent Amino Acids C

Common Amino Acids GW

Mass 5135.05

PI 10.55

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 23

Net Charge +4

Boman Index -4.22

Hydrophobicity -0.151

Aliphatic Index 86.28

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 30480

Absorbance 280nm 593.57

Polar Residues 7

number

4

A

3

R

1

N

1

D

0

C

1

E

2

Q

5

G

1

H

4

I

3

L

3

K

2

M

1

F

1

P

1

S

1

T

5

W

2

Y

2

V

Amino Acid Distribution

A: 4 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 5 H: 1 I: 4 L: 3 K: 3 M: 2 F: 1 P: 1 S: 1 T: 1 W: 5 Y: 2 V: 2

Length

43

Formula

C243H359N65O55S2

Mass

5135.05

PI

10.55

Net Charge

+4

Boman Index

-4.22

Hydrophobicity

-0.151

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.67-1.34 µM

Target

Target Organism S. pnumoniae

Source & Reference

Database Source NA

Other

Evidence Text

19111, S. aureus ATCC 25923, E. faecalis ATCC 29212, E. faecalis BGZLS10-27, S. pyogenes, S. pnumoniae (MIC 0.67-1.34 uM), B. subtilis subsp. subtilis ATCC23857, and B. cereus ATCC 11778 (MIC 5.3 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.3 µM

Target

Target Organism B. cereus ATCC 11778

Source & Reference

Database Source NA

Other

Evidence Text

S. pyogenes, S. pnumoniae (MIC 0.67-1.34 uM), B. subtilis subsp. subtilis ATCC23857, and B. cereus ATCC 11778 (MIC 5.3 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.67-1.34 µM

Target

Target Organism S. pnumoniae

Source & Reference

Database Source Antifungipept

Other

Evidence Text

19111, S. aureus ATCC 25923, E. faecalis ATCC 29212, E. faecalis BGZLS10-27, S. pyogenes, S. pnumoniae (MIC 0.67-1.34 uM), B. subtilis subsp. subtilis ATCC23857, and B. cereus ATCC 11778 (MIC 5.3 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.3 µM

Target

Target Organism B. cereus ATCC 11778

Source & Reference

Database Source Antifungipept

Other

Evidence Text

S. pyogenes, S. pnumoniae (MIC 0.67-1.34 uM), B. subtilis subsp. subtilis ATCC23857, and B. cereus ATCC 11778 (MIC 5.3 uM).