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Peptide record

TPDB11989

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier standard

42 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11989

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 42-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

FASTA

>TPDB11989|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Blood-Brain Barrier|length=42
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Formula C203H311N55O60S1

Absent Amino Acids CPTW

Common Amino Acids GV

Mass 4514.10

PI 5.21

Basic Residues 6

Acidic Residues 6

Hydrophobic Residues 20

Net Charge -3

Boman Index 9.87

Hydrophobicity 0.205

Aliphatic Index 97.38

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 33.01

Polar Residues 5

number

Amino Acid Distribution

A: 4 R: 1 N: 1 D: 3 C: 0 E: 3 Q: 1 G: 6 H: 3 I: 3 L: 2 K: 2 M: 1 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 6

Length

Formula

C203H311N55O60S1

Mass

4514.10

5.21

Net Charge

-3

Boman Index

9.87

Hydrophobicity

0.205

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 u

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.25 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 ug/ml), E. faecalis (MIC 6.25 ug/ml), S. agalactiae (MIC 12.5

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP

Other

Evidence Text

epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 ug/ml), E. faecalis (MIC 6.25 ug/ml), S. agalactiae (MIC 12.5 ug/ml), P-aeruginosa (MIC>50 ug/ml

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP

Other

Evidence Text

eumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 ug/ml), E. faecalis (MIC 6.25 ug/ml), S. agalactiae (MIC 12.5 ug/ml), P-aeruginosa (MIC>50 ug/ml), S-pyogenes (MIC>50 ug/ml),

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Streptococcus agalactiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 ug/ml), E. faecalis (MIC 6.25 ug/ml), S. agalactiae (MIC 12.5 ug/ml), P-aeruginosa (MIC>50 ug/ml), S-pyogenes (MIC>50 ug/ml), S-mitis (MIC>50 ug/ml), abd S-sa

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.78 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.13 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 u

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.25 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.25 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism Streptococcus agalactiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.78 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.56 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.13 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 u

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5.25 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.25 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism Streptococcus agalactiae

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.78 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.56 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.13 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

active against C. albicans (MIC 0.78 ug/ml), E. coli (MIC 1.56 ug/ml), S. epidermidis (MIC 3.13 ug/ml), S .pneumoniae (MIC 6.25 ug/ml), S. aureus (MIC 5.25 ug/ml), L. monocytogenes (MIC 6.25 u

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 5.25 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.25 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µg/mL

Target

Target Organism Streptococcus agalactiae

Source & Reference

Database Source NA

Other

Evidence Text