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Peptide record

TPDB11975

Antibacterial Antifungal standard
42 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11975
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 42-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
GFGCPGDAYQCSEHCRALGGGRTGGYCAGPWYLGHPTCTCSF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C186H264N54O56S6
NIKMV
G
4344.83
6.91
4
2
11
-0
0.82
-0.229
25.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10345
2.38
15
Residue Composition
number
3
A
2
R
0
N
1
D
6
C
1
E
1
Q
10
G
2
H
0
I
2
L
0
K
0
M
2
F
3
P
2
S
3
T
1
W
3
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 1 C: 6 E: 1 Q: 1 G: 10 H: 2 I: 0 L: 2 K: 0 M: 0 F: 2 P: 3 S: 2 T: 3 W: 1 Y: 3 V: 0
Chemical Descriptors
42 reviewed residue count
C186H264N54O56S6 sequence-only estimate (linear, free termini)
4344.83 sequence-only estimate (linear, free termini)
6.91 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
0.82 sequence-only estimate (linear, free termini)
-0.229 sequence-only estimate (linear, free termini)
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.25 µg/mL

Target

S. pneumonia ATCC49619

Source & Reference

NA

Other

Active against S. pneumonia ATCC49619 (MIC 0.25 ug/ml), S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624
Evidence 2 Activity

Activity

MIC
Antibacterial
0.06-1 µg/mL

Target

Streptococcus agalactiae

Source & Reference

NA

Other

Active against S. pneumonia ATCC49619 (MIC 0.25 ug/ml), S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus epidermidis ATCC12228

Source & Reference

NA

Other

S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and E. faecalis ATCC29212 (MIC 2 ug/ml). Activity against Gram- bacteria not detected at
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

, S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and E. faecalis ATCC29212 (MIC 2 ug/ml). Activity against Gram- bacteria not detected at 32 uM (MIC >32 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
0.25 µg/mL

Target

S. pneumonia ATCC49619

Source & Reference

Antifungipept

Other

Active against S. pneumonia ATCC49619 (MIC 0.25 ug/ml), S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624
Evidence 6 Activity

Activity

MIC
Antifungal
0.06-1 µg/mL

Target

Streptococcus agalactiae

Source & Reference

Antifungipept

Other

Active against S. pneumonia ATCC49619 (MIC 0.25 ug/ml), S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and
Evidence 7 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus epidermidis ATCC12228

Source & Reference

Antifungipept

Other

S. pyogenes, S. agalactiae (MIC 0.06-1 ug/ml), S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and E. faecalis ATCC29212 (MIC 2 ug/ml). Activity against Gram- bacteria not detected at
Evidence 8 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

Antifungipept

Other

, S. aureus ATCC29213, E. faecium ATCC49624, S. epidermidis ATCC12228 (MIC 16 ug/ml), and E. faecalis ATCC29212 (MIC 2 ug/ml). Activity against Gram- bacteria not detected at 32 uM (MIC >32 ug/ml).