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Peptide record

TPDB11970

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB11970
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete PD_Hemolysis
standard
No
A 42-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SPIHACRYQRGVCIPGPCRWPYYRVGSCGSGLKSCCVRNRWA
Physicochemical Analysis
C205H317N67O52S6
DEMFT
RC
4744.55
9.59
8
0
13
+7
0.91
-0.343
53.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
15845
333.96
15
Residue Composition
number
2
A
6
R
1
N
0
D
6
C
0
E
1
Q
5
G
1
H
2
I
1
L
1
K
0
M
0
F
4
P
4
S
0
T
2
W
3
Y
3
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 6 E: 0 Q: 1 G: 5 H: 1 I: 2 L: 1 K: 1 M: 0 F: 0 P: 4 S: 4 T: 0 W: 2 Y: 3 V: 3
Chemical Descriptors
42
C205H317N67O52S6
4744.55
9.59
+7
0.91
-0.343
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>42.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | >42.5 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Expression in Pichia Pastoris and biological activity of Avian ?-defensin 6 and its mutant peptide without cysteines. | Protein Pept Lett | 2012
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
30 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 30 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial activity against Salmonella serovars. | Biochem Biophys Res Commun | 2007
Evidence 3 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.