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Peptide record

TPDB11969

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB11969
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifp CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 42-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KNIGNSVSCLRNKGVCMPGKCAPKMKQIGTCGMPQVKCCKRK
Physicochemical Analysis
C186H331N61O51S9
DEHFWY
K
4526.59
10.33
10
0
10
+10
10.49
-0.450
50.95
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
375
8.28
14
Residue Composition
number
1
A
2
R
3
N
0
D
6
C
0
E
2
Q
5
G
0
H
2
I
1
L
8
K
3
M
0
F
3
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 0 C: 6 E: 0 Q: 2 G: 5 H: 0 I: 2 L: 1 K: 8 M: 3 F: 0 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
42
C186H331N61O51S9
4526.59
10.33
+10
10.49
-0.450
Evidence Records 4 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
5 10 10 %
[Ref.23220638]5% hemolytic activity at 10 µg/mL, 10% hemolytic activity at 20 µg/mL, 10% hemolytic activity at 100 µg/mL against porcine fresh blood

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Expr Purif. 2013 Mar 88(1):47-53.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

11% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
11% Hemolysis | 100 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Cloning, expression and characterization of antimicrobial porcine ? defensin 1 in Escherichia coli. | Protein Expr Purif | 2013
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23220638]5% hemolytic activity at 10 µg/mL, 10% hemolytic activity at 20 µg/mL, 10% hemolytic activity at 100 µg/mL against porcine fresh blood

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Expr Purif. 2013 Mar 88(1):47-53.
Evidence 4 Hemolysis

Activity

5 10 10 %
% Hemolysis
[Ref.23220638]5% hemolytic activity at 10 µg/mL, 10% hemolytic activity at 20 µg/mL, 10% hemolytic activity at 100 µg/mL against porcine fresh blood
Hemolysis

Source & Reference

HemoPI PD_Hemolysis
Protein Expr Purif. 2013 Mar 88(1):47-53.
DRAMP4
PD_Hemolysis