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Peptide record

TPDB11968

Antibacterial Antifungal standard
42 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11968
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 42-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
LPLNTIPRPPYFPGKLPPRGGHLFPPTCVCVRSPCPCDQNWG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C211H320N58O52S4
AEM
P
4629.46
8.72
5
1
11
+3
0.98
-0.345
60.24
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
7240
1.56
11
Residue Composition
number
0
A
3
R
2
N
1
D
4
C
0
E
1
Q
4
G
1
H
1
I
4
L
1
K
0
M
2
F
11
P
1
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 1 C: 4 E: 0 Q: 1 G: 4 H: 1 I: 1 L: 4 K: 1 M: 0 F: 2 P: 11 S: 1 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
42 reviewed residue count
C211H320N58O52S4 sequence-only estimate (linear, free termini)
4629.46 sequence-only estimate (linear, free termini)
8.72 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.98 sequence-only estimate (linear, free termini)
-0.345 sequence-only estimate (linear, free termini)
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

M. luteus SDMCC210058

Source & Reference

NA

Other

Active against Gram+ S. aureus AS1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

A. hydrohila

Source & Reference

NA

Other

against Gram+ S. aureus AS1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-term
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli DH5alpha

Source & Reference

NA

Other

S1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-terminal Pro-rich domain is proposed
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

V. anguillarum SDMCC210204

Source & Reference

NA

Other

210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-terminal Pro-rich domain is proposed to be essential for activity. Updated 7/2021
Evidence 5 Activity

Activity

MIC
Antifungal
6.25 µM

Target

M. luteus SDMCC210058

Source & Reference

Antifungipept

Other

Active against Gram+ S. aureus AS1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC
Evidence 6 Activity

Activity

MIC
Antifungal
25 µM

Target

A. hydrohila

Source & Reference

Antifungipept

Other

against Gram+ S. aureus AS1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-term
Evidence 7 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli DH5alpha

Source & Reference

Antifungipept

Other

S1.89 (MIC 12.5 uM), M. luteus SDMCC210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-terminal Pro-rich domain is proposed
Evidence 8 Activity

Activity

MIC
Antifungal
6.25 µM

Target

V. anguillarum SDMCC210204

Source & Reference

Antifungipept

Other

210058 (MIC 6.25 uM), Gram- A. hydrohila (MIC 25 uM), E. coli DH5alpha (MIC 12.5 uM), and V. anguillarum SDMCC210204 (MIC 6.25 uM). The N-terminal Pro-rich domain is proposed to be essential for activity. Updated 7/2021