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Peptide record

TPDB11963

Antibacterial Antifungal Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB11963
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 42-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFH
Physicochemical Analysis
C242H389N77O55
CMPTW
K
5257.23
11.56
18
4
14
+11
15.01
-1.217
65.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
28.34
4
Residue Composition
number
1
A
6
R
1
N
2
D
0
C
2
E
1
Q
3
G
3
H
3
I
3
L
9
K
0
M
5
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 1 D: 2 C: 0 E: 2 Q: 1 G: 3 H: 3 I: 3 L: 3 K: 9 M: 0 F: 5 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
42
C242H389N77O55
5257.23
11.56
+11
15.01
-1.217
Evidence Records 3 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. | Gene | 2018
Evidence 2 Activity

Activity

12.0±0.7% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
12.0±0.7% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. | Gene | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.29859288] Hemolysis 12.0 ± 0.7% at 500 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Gene. 2018 May 30. pii: S0378-1119(18)30617-6.