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Peptide record

TPDB11945

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB11945
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP AVPpred-BWR DRAVP 2.0 BBPpredict
standard
No
A 41-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
Physicochemical Analysis
C188H311N55O50S6
NEMW
CG
4334.24
9.24
8
1
10
+6
6.61
-0.102
64.15
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
43.03
12
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
0
E
1
Q
6
G
1
H
3
I
2
L
5
K
0
M
1
F
5
P
1
S
3
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 1 G: 6 H: 1 I: 3 L: 2 K: 5 M: 0 F: 1 P: 5 S: 1 T: 3 W: 0 Y: 1 V: 2
Chemical Descriptors
41
C188H311N55O50S6
4334.24
9.24
+6
6.61
-0.102
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 2 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 3 Activity

Activity

11% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
11% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. | Biopolymers | 2005
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.15625724] It is slightly hemolytic (<12%) against human erythrocytes at the highest concentration of 500 µg/ml.

Target

erythrocytes

Source & Reference

NA
DRAMP
Nature. 1997 Jun 26 387(6636):861.##J Biol Chem. 2000 Oct 20 275(42):32911-32918.##Plant Cell Rep. 2007 Aug 26(8):1391-1398.