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Peptide record

TPDB11915

Antibacterial Antifungal standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB11915
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 40-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
MTPFWRGVSLRPIGASCRDNSECITMLCRKNRCFLRSASE
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C193H316N62O56S6
QHY
R
4593.37
9.32
7
3
13
+4
2.51
-0.278
61.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5750
1.25
13
Residue Composition
number
2
A
6
R
2
N
1
D
4
C
2
E
0
Q
2
G
0
H
2
I
3
L
1
K
2
M
2
F
2
P
5
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 2 D: 1 C: 4 E: 2 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 1 M: 2 F: 2 P: 2 S: 5 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
40 reviewed residue count
C193H316N62O56S6 sequence-only estimate (linear, free termini)
4593.37 sequence-only estimate (linear, free termini)
9.32 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.51 sequence-only estimate (linear, free termini)
-0.278 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against S. aureus, E. coli (90% killing at 50 ug/mL), and L. monocytogenes by membrane permeation. more active against Gram+. 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against S. aureus, E. coli (90% killing at 50 ug/mL), and L. monocytogenes by membrane permeation. more active against Gram+. 7/2021