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Peptide record

TPDB11911

β-Amyloid1-40 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier standard
40 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11911
β-Amyloid1-40
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb AI4AVP DRAVP 2.0 BBPpredict
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Physicochemical Analysis
C194H295N53O58S1
CPTW
GV
4329.86
5.21
6
6
18
-3
10.35
0.058
90.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
34.41
5
Residue Composition
number
3
A
1
R
1
N
3
D
0
C
3
E
1
Q
6
G
3
H
2
I
2
L
2
K
1
M
3
F
0
P
2
S
0
T
0
W
1
Y
6
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 3 C: 0 E: 3 Q: 1 G: 6 H: 3 I: 2 L: 2 K: 2 M: 1 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 6
Chemical Descriptors
40
C194H295N53O58S1
4329.86
5.21
-3
10.35
0.058
Linear
Similarity
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N
Evidence Records 34 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumo
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S.
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

ive against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monoc
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. ag
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

L. monocytogenes ATCC 19112

Source & Reference

dbAMP

Other

0 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aerugi
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyoge
Evidence 7 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Streptococcus agalactiae ATCC 12386

Source & Reference

dbAMP

Other

g/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis A
Evidence 8 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

S. mitis ATCC 6249

Source & Reference

dbAMP

Other

50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis ATCC 6249 (MIC 50 ug/ml), abd S-salivarius ATCC 13419 (MIC > 50 ug/ml). It also inhibits Herpes simplex virus 1 (H
Evidence 9 Activity

Activity

MIC
Antifungal
0.78 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumo
Evidence 10 Activity

Activity

MIC
Antifungal
1.56 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S.
Evidence 11 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ive against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monoc
Evidence 12 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. ag
Evidence 13 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

L. monocytogenes ATCC 19112

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aerugi
Evidence 14 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyoge
Evidence 15 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Streptococcus agalactiae ATCC 12386

Source & Reference

dbAMP CAFPdb Antifungipept

Other

g/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis A
Evidence 16 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

S. mitis ATCC 6249

Source & Reference

dbAMP CAFPdb Antifungipept

Other

50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis ATCC 6249 (MIC 50 ug/ml), abd S-salivarius ATCC 13419 (MIC > 50 ug/ml). It also inhibits Herpes simplex virus 1 (H
Evidence 17 Activity

Activity

MIC
Antiparasitic
0.78 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumo
Evidence 18 Activity

Activity

MIC
Antiparasitic
1.56 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S.
Evidence 19 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

ive against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monoc
Evidence 20 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. ag
Evidence 21 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

L. monocytogenes ATCC 19112

Source & Reference

NA

Other

0 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aerugi
Evidence 22 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyoge
Evidence 23 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Streptococcus agalactiae ATCC 12386

Source & Reference

NA

Other

g/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis A
Evidence 24 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

S. mitis ATCC 6249

Source & Reference

NA

Other

50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis ATCC 6249 (MIC 50 ug/ml), abd S-salivarius ATCC 13419 (MIC > 50 ug/ml). It also inhibits Herpes simplex virus 1 (H
Evidence 25 Activity

Activity

MIC
Antiviral
0.78 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

DRAVP 2.0

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumo
Evidence 26 Activity

Activity

MIC
Antiviral
1.56 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAVP 2.0

Other

active against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S.
Evidence 27 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

DRAVP 2.0

Other

ive against C. albicans ATCC 10231 (MIC 0.78 ug/ml), E. coli ATCC 25922 (MIC 1.56 ug/ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monoc
Evidence 28 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAVP 2.0

Other

ml), S. epidermidis ATCC 12228 (MIC 50 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. ag
Evidence 29 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

L. monocytogenes ATCC 19112

Source & Reference

DRAVP 2.0

Other

0 ug/ml), S .pneumoniae ATCC 49619 (MIC 12.5 ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aerugi
Evidence 30 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAVP 2.0

Other

ug/ml), S. aureus ATCC 25923 (MIC 25 ug/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyoge
Evidence 31 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

Streptococcus agalactiae ATCC 12386

Source & Reference

DRAVP 2.0

Other

g/ml), L. monocytogenes ATCC 19112 (MIC 25 ug/ml), E. faecalis ATCC 29212 (MIC 50 ug/ml), S. agalactiae ATCC 12386 (MIC 50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis A
Evidence 32 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

S. mitis ATCC 6249

Source & Reference

DRAVP 2.0

Other

50 ug/ml), P-aeruginosa ATCC 27853 (MIC>50 ug/ml), S-pyogenes ATCC 19615 (MIC>50 ug/ml), S. mitis ATCC 6249 (MIC 50 ug/ml), abd S-salivarius ATCC 13419 (MIC > 50 ug/ml). It also inhibits Herpes simplex virus 1 (H
Evidence 33 Activity

Activity

Blood-Brain Barrier
0.00234 mL/(g x min)

Assay & Model

Capillary deplition in situ b p
Origin/Source
Unidirectonal influx rate constant

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 34 Activity

Activity

Blood-Brain Barrier
7 (cpm brain/mg)/(cpm blood/µl)

Assay & Model

Origin/Source
RadioactiInitial disrobution volumety ratio

Source & Reference

NA
B3Pdb

Other

human
Intravenous
Permeability
direct iodination
Additional Detail Fields 1 fields
Intravenous