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Peptide record

TPDB11897

Antibacterial Anticancer Antifungal Antiparasitic standard
40 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11897
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN
Physicochemical Analysis
C164H272N58O52S6
EQMFPW
CG
4080.68
8.31
6
1
13
+3
3.21
0.102
75.75
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
45.70
15
Residue Composition
number
5
A
3
R
4
N
1
D
6
C
0
E
0
Q
6
G
2
H
1
I
4
L
1
K
0
M
0
F
0
P
2
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 5 R: 3 N: 4 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 2 I: 1 L: 4 K: 1 M: 0 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
40
C164H272N58O52S6
4080.68
8.31
+3
3.21
0.102
Evidence Records 39 records
Evidence 1 Activity

Activity

IC50
Antibacterial
<0.2 µg/mL

Target

C. glutamicum ATCC1 3059

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6
Evidence 2 Activity

Activity

IC50
Antibacterial
0.5 µg/mL

Target

Staphylococcus aureus ATCC6538B

Source & Reference

dbAMP DRAMP

Other

B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t
Evidence 3 Activity

Activity

IC50
Antibacterial
1.0 µg/mL

Target

Staphylococcus epidermidis IFO 3762

Source & Reference

dbAMP DRAMP

Other

IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (I
Evidence 4 Activity

Activity

IC50
Antibacterial
4.5 µg/mL

Target

S. mutans 6515t

Source & Reference

dbAMP DRAMP

Other

<0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27
Evidence 5 Activity

Activity

IC50
Antibacterial
1.5 µg/mL

Target

S. sanguis ST3t

Source & Reference

dbAMP DRAMP

Other

(IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active
Evidence 6 Activity

Activity

IC50
Antibacterial
2.6 µg/mL

Target

S. salivarius HHTt

Source & Reference

dbAMP DRAMP

Other

O 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L
Evidence 7 Activity

Activity

IC50
Antibacterial
5.2 µg/mL

Target

Streptococcus bovis ATCC27960t

Source & Reference

dbAMP DRAMP

Other

(IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12
Evidence 8 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

L. lactis

Source & Reference

dbAMP DRAMP

Other

) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC
Evidence 9 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

(IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC
Evidence 10 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

tive against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multoci
Evidence 11 Activity

Activity

MIC
Antibacterial
6 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

actis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 12 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

(MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 13 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP DRAMP

Other

12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 14 Activity

Activity

IC50
Antifungal
<0.2 µg/mL

Target

C. glutamicum ATCC1 3059

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6
Evidence 15 Activity

Activity

IC50
Antifungal
0.5 µg/mL

Target

Staphylococcus aureus ATCC6538B

Source & Reference

dbAMP DRAMP Antifungipept

Other

B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t
Evidence 16 Activity

Activity

IC50
Antifungal
1.0 µg/mL

Target

Staphylococcus epidermidis IFO 3762

Source & Reference

dbAMP DRAMP Antifungipept

Other

IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (I
Evidence 17 Activity

Activity

IC50
Antifungal
4.5 µg/mL

Target

S. mutans 6515t

Source & Reference

dbAMP DRAMP Antifungipept

Other

<0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27
Evidence 18 Activity

Activity

IC50
Antifungal
1.5 µg/mL

Target

S. sanguis ST3t

Source & Reference

dbAMP DRAMP Antifungipept

Other

(IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active
Evidence 19 Activity

Activity

IC50
Antifungal
2.6 µg/mL

Target

S. salivarius HHTt

Source & Reference

dbAMP DRAMP Antifungipept

Other

O 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L
Evidence 20 Activity

Activity

IC50
Antifungal
5.2 µg/mL

Target

Streptococcus bovis ATCC27960t

Source & Reference

dbAMP DRAMP Antifungipept

Other

(IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12
Evidence 21 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

L. lactis

Source & Reference

dbAMP DRAMP Antifungipept

Other

) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC
Evidence 22 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP Antifungipept

Other

(IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC
Evidence 23 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP Antifungipept

Other

tive against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multoci
Evidence 24 Activity

Activity

MIC
Antifungal
6 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

actis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 25 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 26 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

P. multocida

Source & Reference

dbAMP DRAMP Antifungipept

Other

12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 27 Activity

Activity

IC50
Antiparasitic
<0.2 µg/mL

Target

C. glutamicum ATCC1 3059

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6
Evidence 28 Activity

Activity

IC50
Antiparasitic
0.5 µg/mL

Target

Staphylococcus aureus ATCC6538B

Source & Reference

DRAMP

Other

B. megaterium IAM 1166, B. circulans IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t
Evidence 29 Activity

Activity

IC50
Antiparasitic
1.0 µg/mL

Target

Staphylococcus epidermidis IFO 3762

Source & Reference

DRAMP

Other

IFO 3967, C. glutamicum ATCC1 3059(IC50 <0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (I
Evidence 30 Activity

Activity

IC50
Antiparasitic
4.5 µg/mL

Target

S. mutans 6515t

Source & Reference

DRAMP

Other

<0.2ug/ml), S. aureus ATCC6538B (IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27
Evidence 31 Activity

Activity

IC50
Antiparasitic
1.5 µg/mL

Target

S. sanguis ST3t

Source & Reference

DRAMP

Other

(IC50 0.5ug/ml), S. epidermidis IFO 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active
Evidence 32 Activity

Activity

IC50
Antiparasitic
2.6 µg/mL

Target

S. salivarius HHTt

Source & Reference

DRAMP

Other

O 3762(IC50 1.0ug/ml), S. mutans 6515t (IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L
Evidence 33 Activity

Activity

IC50
Antiparasitic
5.2 µg/mL

Target

Streptococcus bovis ATCC27960t

Source & Reference

DRAMP

Other

(IC50 4.5ug/ml), S. sanguis ST3t (IC50 1.5 ug/ml), S. salivarius HHTt (IC50 2.6ug/ml) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12
Evidence 34 Activity

Activity

MIC
Antiparasitic
3 µg/mL

Target

L. lactis

Source & Reference

DRAMP

Other

) and S. bovis ATCC27960t (IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC
Evidence 35 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

(IC50 5.2 ug/ml). Also active against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC
Evidence 36 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

tive against Active against S. uberis, L. lactis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multoci
Evidence 37 Activity

Activity

MIC
Antiparasitic
6 µg/mL

Target

Staphylococcus aureus MRSA

Source & Reference

DRAMP

Other

actis (MIC 3 ug/ml), M. luteus (MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 38 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

B. cereus

Source & Reference

DRAMP

Other

(MIC 12 ug/ml), S. epidermidis (MIC 12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).
Evidence 39 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

P. multocida

Source & Reference

DRAMP

Other

12 ug/ml), L. innocua, S. aureus MRSA (MIC 6 ug/ml), B. cereus (MIC 25 ug/ml), and Gram- P. multocida (MIC 25 ug/ml).