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Peptide record

TPDB11893

Antibacterial Anticancer Antifungal Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB11893
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ATCDLLSPFKVGHAACAAHCIARGKRGGWCDKRAVCNCRK
Physicochemical Analysis
C179H294N62O48S6
EQMY
A
4275.05
9.32
10
2
14
+6
5.86
-0.130
61.25
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5875
137.43
9
Residue Composition
number
7
A
4
R
1
N
2
D
6
C
0
E
0
Q
4
G
2
H
1
I
2
L
4
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 7 R: 4 N: 1 D: 2 C: 6 E: 0 Q: 0 G: 4 H: 2 I: 1 L: 2 K: 4 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
40
C179H294N62O48S6
4275.05
9.32
+6
5.86
-0.130
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
14.99 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

Active against MRSA S. aureus 40881, 12256 or CVCC 546 (MIC 3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (
Evidence 2 Activity

Activity

MIC
Antibacterial
7.5 µM

Target

S. pneumoniae CVCC 2350

Source & Reference

NA

Other

aureus 40881, 12256 or CVCC 546 (MIC 3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against
Evidence 3 Activity

Activity

MIC
Antibacterial
3.75 µM

Target

S. suis CVCC 3928

Source & Reference

NA

Other

3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against G- bacteria tested E.coli CVCC151
Evidence 4 Activity

Activity

MIC
Antibacterial
0.02-0.04 µM

Target

B. subtilis

Source & Reference

NA

Other

MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against G- bacteria tested E.coli CVCC1515 (MIC >128 ug/ml ~30 uM), E.coli C
Evidence 5 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

S.enteritidis CMCC50336

Source & Reference

NA

Other

5 (MIC >128 ug/ml ~30 uM), E.coli CICC21530 (serotype O157:H7), S.typhimurium ATCC14028, S.enteritidis CMCC50336 (MIC >128 ug/ml). Activity also from Li (et al., 2020) .
Evidence 6 Activity

Activity

MIC
Antifungal
14.99 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

CAFPdb Antifungipept

Other

Active against MRSA S. aureus 40881, 12256 or CVCC 546 (MIC 3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (
Evidence 7 Activity

Activity

MIC
Antifungal
7.5 µM

Target

S. pneumoniae CVCC 2350

Source & Reference

CAFPdb Antifungipept

Other

aureus 40881, 12256 or CVCC 546 (MIC 3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against
Evidence 8 Activity

Activity

MIC
Antifungal
3.75 µM

Target

S. suis CVCC 3928

Source & Reference

CAFPdb Antifungipept

Other

3.75 uM), S. epidermidis ATCC 12228 (MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against G- bacteria tested E.coli CVCC151
Evidence 9 Activity

Activity

MIC
Antifungal
0.02-0.04 µM

Target

B. subtilis

Source & Reference

CAFPdb Antifungipept

Other

MIC 14.99 uM), S. pneumoniae CVCC 2350 (MIC 7.5 uM), S. suis CVCC 3928 (MIC 3.75 uM), and B. subtilis (MIC 0.02-0.04 uM). Not active against G- bacteria tested E.coli CVCC1515 (MIC >128 ug/ml ~30 uM), E.coli C
Evidence 10 Activity

Activity

MIC
Antifungal
>128 µg/mL

Target

S.enteritidis CMCC50336

Source & Reference

CAFPdb Antifungipept

Other

5 (MIC >128 ug/ml ~30 uM), E.coli CICC21530 (serotype O157:H7), S.typhimurium ATCC14028, S.enteritidis CMCC50336 (MIC >128 ug/ml). Activity also from Li (et al., 2020) .
Evidence 11 Activity

Activity

1.46% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
1.46% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus. | Sci Rep | 2017
Evidence 12 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022