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Peptide record

TPDB11873

Anti-inflammatory Antibacterial Antifungal Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB11873
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 Antifungipept
standard
No
A 40-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, and Antifungipept, with an available 3D structural model.
Sequence
GWLKKLGKKIERVGQHTRDATIQTIGVAQQAVNVAATLKG
Physicochemical Analysis
C189H323N59O54
CMFPSY
AGK
4286.01
11.08
8
2
16
+5
9.10
-0.280
100.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
128.32
9
Residue Composition
number
5
A
2
R
1
N
1
D
0
C
1
E
4
Q
5
G
1
H
3
I
3
L
5
K
0
M
0
F
0
P
0
S
4
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 4 G: 5 H: 1 I: 3 L: 3 K: 5 M: 0 F: 0 P: 0 S: 0 T: 4 W: 1 Y: 0 V: 4
Chemical Descriptors
40
C189H323N59O54
4286.01
11.08
+5
9.10
-0.280
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.8 µg/mL

Target

Escherichia coli DH10B

Source & Reference

NA

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 2 Activity

Activity

MIC
Antibacterial
15.6 µg/mL

Target

Escherichia coli ESBL

Source & Reference

NA

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 3 Activity

Activity

MIC
Antibacterial
125 µg/mL

Target

E.cloacae

Source & Reference

NA

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 4 Activity

Activity

MIC
Antifungal
7.8 µg/mL

Target

Escherichia coli DH10B

Source & Reference

Antifungipept

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 5 Activity

Activity

MIC
Antifungal
15.6 µg/mL

Target

Escherichia coli ESBL

Source & Reference

Antifungipept

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 6 Activity

Activity

MIC
Antifungal
125 µg/mL

Target

E.cloacae

Source & Reference

Antifungipept

Other

Active against E. coli DH10B (MIC 7.8 ug/ml) and E. coli ESBL (MIC 15.6 ug/ml). Inactive: E.cloacae (MIC 125ug/ml). MBC similar.
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification, Characterization, Immunolocalization, and Biological Activity of Lucilin Peptide. | Acta Trop | 2018
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Identification, Characterization, Immunolocalization, and Biological Activity of Lucilin Peptide. | Acta Trop | 2018
Evidence 9 Activity

Activity

IC50
Toxicity
58.30 µg/mL
Cytotoxic
IC50 | 58.30 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Identification, Characterization, Immunolocalization, and Biological Activity of Lucilin Peptide. | Acta Trop | 2018