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Peptide record

TPDB11858

Antibacterial Anticancer Antifungal Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB11858
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GWLRDFGKRIERTGQNIRDATIQTIGIAQEAANVAATLK
Physicochemical Analysis
C186H309N59O57
CHMPSY
A
4283.86
10.56
6
4
16
+2
8.30
-0.377
92.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
128.39
9
Residue Composition
number
6
A
4
R
2
N
2
D
0
C
2
E
3
Q
4
G
0
H
5
I
2
L
2
K
0
M
1
F
0
P
0
S
4
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 6 R: 4 N: 2 D: 2 C: 0 E: 2 Q: 3 G: 4 H: 0 I: 5 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 4 W: 1 Y: 0 V: 1
Chemical Descriptors
39
C186H309N59O57
4283.86
10.56
+2
8.30
-0.377
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-32 µg/mL

Target

Escherichia coli D31 or ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Amidated is more active against E. coli D31 or ATCC 25922 (MIC 4-32 µg/mL), K. pneumoniae DSM 30104 (16 µg/mL), A. baumannii ATCC 19606 (MIC 8 µg/mL).
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP

Other

e against E. coli D31 or ATCC 25922 (MIC 4-32 µg/mL), K. pneumoniae DSM 30104 (16 µg/mL), A. baumannii ATCC 19606 (MIC 8 µg/mL).
Evidence 3 Activity

Activity

MIC
Antifungal
4-32 µg/mL

Target

Escherichia coli D31 or ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Amidated is more active against E. coli D31 or ATCC 25922 (MIC 4-32 µg/mL), K. pneumoniae DSM 30104 (16 µg/mL), A. baumannii ATCC 19606 (MIC 8 µg/mL).
Evidence 4 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e against E. coli D31 or ATCC 25922 (MIC 4-32 µg/mL), K. pneumoniae DSM 30104 (16 µg/mL), A. baumannii ATCC 19606 (MIC 8 µg/mL).
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptides from Rat-Tailed Maggots of the Drone Fly Eristalis tenax Show Potent Activity against Multidrug-Resistant Gram-Negative Bacteria. | Microorganisms | 2020
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 512 µg/ml | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Microorganisms. 2020 Apr 25 8(5):626