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Peptide record

TPDB11840

Antibacterial Antifungal Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB11840
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SYVGDCGSNGGSCVSSYCPYGNRLNYFCPLGRTCCRRSY
Physicochemical Analysis
C178H266N54O57S6
AEQHIKMW
CGS
4266.76
8.29
4
1
10
+3
-0.64
-0.405
34.87
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
7825
183.39
21
Residue Composition
number
0
A
4
R
3
N
1
D
6
C
0
E
0
Q
6
G
0
H
0
I
2
L
0
K
0
M
1
F
2
P
6
S
1
T
0
W
5
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 3 D: 1 C: 6 E: 0 Q: 0 G: 6 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 2 S: 6 T: 1 W: 0 Y: 5 V: 2
Chemical Descriptors
39
C178H266N54O57S6
4266.76
8.29
+3
-0.64
-0.405
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli, K. pneumonia, S. aureus, B. subtilis, and C. albicans.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli, K. pneumonia, S. aureus, B. subtilis, and C. albicans.
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Panusin represents a new family of β-defensin-like peptides in invertebrates. | Dev Comp Immunol | 2016
Evidence 4 Activity

Activity

0.6±0.02% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
0.6±0.02% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
The C-Terminus of Panusin, a Lobster β-Defensin, Is Crucial for Optimal Antimicrobial Activity and Serum Stability | Pharmaceutics | 2023
Evidence 5 Activity

Activity

IC50
Toxicity
145±1.7 µM
Cytotoxic
IC50 | 145±1.7 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
The C-Terminus of Panusin, a Lobster β-Defensin, Is Crucial for Optimal Antimicrobial Activity and Serum Stability | Pharmaceutics | 2023