TPDB

3D PDB MODEL

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TPDB ID TPDB11838

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVEYHK

FASTA

>TPDB11838|Antibacterial;Antifungal|length=39
GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVEYHK

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

Formula C195H320N54O52S2

Absent Amino Acids QM

Common Amino Acids K

Mass 4317.14

PI 10.05

Basic Residues 9

Acidic Residues 3

Hydrophobic Residues 15

Net Charge +5

Boman Index 1.14

Hydrophobicity -0.182

Aliphatic Index 94.87

N-end Rule Half-life Estimate

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 1.65

Polar Residues 8

number

2

A

1

R

2

N

2

D

2

C

1

E

0

Q

4

G

1

H

3

I

3

L

7

K

0

M

1

F

1

P

2

S

1

T

1

W

1

Y

4

V

Amino Acid Distribution

A: 2 R: 1 N: 2 D: 2 C: 2 E: 1 Q: 0 G: 4 H: 1 I: 3 L: 3 K: 7 M: 0 F: 1 P: 1 S: 2 T: 1 W: 1 Y: 1 V: 4

Length

39 reviewed residue count

Formula

C195H320N54O52S2 sequence-only estimate (linear, free termini)

Mass

4317.14 sequence-only estimate (linear, free termini)

PI

10.05 sequence-only estimate (linear, free termini)

Net Charge

+5 sequence-only estimate (linear, free termini)

Boman Index

1.14 sequence-only estimate (linear, free termini)

Hydrophobicity

-0.182 sequence-only estimate (linear, free termini)

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µM

Target

Target Organism Escherichia coli ATCC 8739

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 6.3 uM), MRSA ATCC 43300 (MIC 100 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µM

Target

Target Organism Staphylococcus aureus ATCC 6538

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 6.3 uM), MRSA ATCC 43300 (MIC 100 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µM

Target

Target Organism Escherichia coli ATCC 8739

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 6.3 uM), MRSA ATCC 43300 (MIC 100 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µM

Target

Target Organism Staphylococcus aureus ATCC 6538

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli ATCC 8739 (MIC 6.3 uM), S. aureus ATCC 6538 (MIC 6.3 uM), MRSA ATCC 43300 (MIC 100 uM).