TPDB

3D PDB MODEL

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TPDB ID TPDB11837

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIW

FASTA

>TPDB11837|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=39
GRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIW

Formula C201H319N57O49S6

Absent Amino Acids NEQHMV

Common Amino Acids C

Mass 4510.46

PI 9.94

Basic Residues 9

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +8

Boman Index -1.09

Hydrophobicity 0.038

Aliphatic Index 62.56

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7365

Absorbance 280nm 163.29

Polar Residues 13

number

1

A

4

R

0

N

1

D

6

C

0

E

0

Q

3

G

0

H

2

I

4

L

5

K

0

M

4

F

1

P

5

S

1

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 4 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 4 K: 5 M: 0 F: 4 P: 1 S: 5 T: 1 W: 1 Y: 1 V: 0

Length

39

Formula

C201H319N57O49S6

Mass

4510.46

PI

9.94

Net Charge

+8

Boman Index

-1.09

Hydrophobicity

0.038

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli ML-35, L. monocytogenes strain EGD and C. albicans. Updated 9/2010 4/2019

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli ML-35, L. monocytogenes strain EGD and C. albicans. Updated 9/2010 4/2019

Evidence 3 Activity

Activity

Detail Source Activity Antiparasitic

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ML-35, L. monocytogenes strain EGD and C. albicans. Updated 9/2010 4/2019

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Chicken macrophages HD-11

Target

Target Cell Chicken macrophages HD-11

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Avian antimicrobial peptides: in vitro and in ovo characterization and protection from early chick mortality caused by yolk sac infection. | Sci Rep | 2021