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Peptide record

TPDB11836

Antibacterial Anticancer Antifungal Antiparasitic standard

39 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11836

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH

FASTA

>TPDB11836|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=39
KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH

Formula C188H313N61O51

Absent Amino Acids CQLMPW

Common Amino Acids K

Mass 4243.93

PI 10.93

Basic Residues 12

Acidic Residues 2

Hydrophobic Residues 15

Net Charge +7

Boman Index 12.50

Hydrophobicity -0.564

Aliphatic Index 82.56

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 35.11

Polar Residues 7

number

Amino Acid Distribution

A: 5 R: 2 N: 3 D: 1 C: 0 E: 1 Q: 0 G: 4 H: 3 I: 4 L: 0 K: 7 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 1 V: 4

Length

Formula

C188H313N61O51

Mass

4243.93

10.93

Net Charge

Boman Index

12.50

Hydrophobicity

-0.564

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 u

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.7 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycel

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

a E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism A. rabiei

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism L. maculans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ngi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 70 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

M), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 u

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.7 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism A. rabiei

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism L. maculans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 70 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

M), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against bacteria E. coli (MIC 10 uM), M. luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 u

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.7 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7 µM

Target

Target Organism A. rabiei

Source & Reference

Database Source DRAMP

Other

Evidence Text

luteus (MIC 10 uM), fungi (spore): F. graminearum (MIC 0.7 uM), F. oxysporum (MIC 10 uM), A. rabiei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7 µM

Target

Target Organism L. maculans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 70 µM

Target

Target Organism F. graminearum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

ei (MIC 7 uM), L. maculans (MIC 7 uM), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism A.niger

Source & Reference

Database Source DRAMP

Other

Evidence Text

M), and fungi (mycelia) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism C.gloeosporioides

Source & Reference

Database Source DRAMP

Other

Evidence Text

) F. graminearum (MIC 70 uM) and F. oxysporum (MIC 7 uM). Inactive: A.niger (MIC>150 uM), C.gloeosporioides (MIC >150 uM). Updated 7/2021