Back to search

Peptide record

TPDB11834

Antibacterial Antifungal Toxicity standard

39 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11834

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

GSKRWRKFEKRVKKVFEHTKEALPVIQGVATVVGAVGRR

FASTA

>TPDB11834|Antibacterial;Antifungal;Toxicity|length=39
GSKRWRKFEKRVKKVFEHTKEALPVIQGVATVVGAVGRR

Formula C201H336N64O50

Absent Amino Acids NDCMY

Common Amino Acids V

Mass 4449.28

PI 11.91

Basic Residues 12

Acidic Residues 3

Hydrophobic Residues 15

Net Charge +8

Boman Index 13.49

Hydrophobicity -0.531

Aliphatic Index 79.74

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 123.62

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 5 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 4 H: 1 I: 1 L: 1 K: 6 M: 0 F: 2 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 7

Length

Formula

C201H336N64O50

Mass

4449.28

11.91

Net Charge

Boman Index

13.49

Hydrophobicity

-0.531

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against Gram- E. coli (MIC 3.1 uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. t

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Enterobacter cloacae clinical isolate

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram- E. coli (MIC 3.1 uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. typhimurium clinical isolate (MIC 6.2 uM),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Klebsiella pneumoniae ATCC BAA 1705

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against Gram- E. coli (MIC 3.1 uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. typhimurium clinical isolate (MIC 6.2 uM), P. aeruginosa ATCC 105663 (MIC 12.5 uM), a

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µM

Target

Target Organism S. typhimurium clinical isolate

Source & Reference

Database Source dbAMP

Other

Evidence Text

uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. typhimurium clinical isolate (MIC 6.2 uM), P. aeruginosa ATCC 105663 (MIC 12.5 uM), and Gram+ S. saprophyticus clinical isolate (MI

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 105663

Source & Reference

Database Source dbAMP

Other

Evidence Text

, K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. typhimurium clinical isolate (MIC 6.2 uM), P. aeruginosa ATCC 105663 (MIC 12.5 uM), and Gram+ S. saprophyticus clinical isolate (MIC 12.5 uM). Updated 7/2021 12/2025

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism S. saprophyticus clinical isolate

Source & Reference

Database Source dbAMP

Other

Evidence Text

imurium clinical isolate (MIC 6.2 uM), P. aeruginosa ATCC 105663 (MIC 12.5 uM), and Gram+ S. saprophyticus clinical isolate (MIC 12.5 uM). Updated 7/2021 12/2025

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against Gram- E. coli (MIC 3.1 uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. t

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Enterobacter cloacae clinical isolate

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram- E. coli (MIC 3.1 uM), E. cloacae clinical isolate (MIC 3.1 uM), K. pneumoniae ATCC BAA 1705 (MIC 3.1 uM), S. typhimurium clinical isolate (MIC 6.2 uM),

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Klebsiella pneumoniae ATCC BAA 1705

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µM

Target

Target Organism S. typhimurium clinical isolate

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 105663

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism S. saprophyticus clinical isolate

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

imurium clinical isolate (MIC 6.2 uM), P. aeruginosa ATCC 105663 (MIC 12.5 uM), and Gram+ S. saprophyticus clinical isolate (MIC 12.5 uM). Updated 7/2021 12/2025

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 250 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel cecropins from the Oxysternon conspicillatum neotropic dung beetle. | PLoS One | 2017

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel cecropins from the Oxysternon conspicillatum neotropic dung beetle. | PLoS One | 2017

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel cecropins from the Oxysternon conspicillatum neotropic dung beetle. | PLoS One | 2017

Evidence 16 Activity

Activity

Activity Endpoint 20% Killing

Detail Source Activity Toxicity

Activity Measurement 250 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

20% Killing | 250 | µg/mL | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel cecropins from the Oxysternon conspicillatum neotropic dung beetle. | PLoS One | 2017