Back to search

Peptide record

TPDB11821

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11821
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ENFFKEIERAGQRIRDAIISAAPAVETLAQAQKIIKGGD
Physicochemical Analysis
C187H309N55O58
CHMWY
A
4255.84
7.23
6
6
17
+0
13.05
-0.290
95.38
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
6
Residue Composition
number
7
A
3
R
1
N
2
D
0
C
4
E
3
Q
3
G
0
H
6
I
1
L
3
K
0
M
2
F
1
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 3 N: 1 D: 2 C: 0 E: 4 Q: 3 G: 3 H: 0 I: 6 L: 1 K: 3 M: 0 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
39
C187H309N55O58
4255.84
7.23
+0
13.05
-0.290
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
34.4 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fun
Evidence 2 Activity

Activity

MIC
Antibacterial
34.4 µM

Target

L. monocytogenes

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
34.4 µM

Target

S. lutea

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against par
Evidence 4 Activity

Activity

MIC
Antibacterial
6.9-8.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC
Evidence 5 Activity

Activity

MIC
Antibacterial
17.2-34.4 µM

Target

A. niger

Source & Reference

dbAMP DRAMP

Other

monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC50 ~ 100 uM) ( Patiño-Márquez et al., 2
Evidence 6 Activity

Activity

MIC
Antifungal
34.4 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fun
Evidence 7 Activity

Activity

MIC
Antifungal
34.4 µM

Target

L. monocytogenes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
34.4 µM

Target

S. lutea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against par
Evidence 9 Activity

Activity

MIC
Antifungal
6.9-8.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC
Evidence 10 Activity

Activity

MIC
Antifungal
17.2-34.4 µM

Target

A. niger

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC50 ~ 100 uM) ( Patiño-Márquez et al., 2
Evidence 11 Activity

Activity

MIC
Antiparasitic
34.4 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fun
Evidence 12 Activity

Activity

MIC
Antiparasitic
34.4 µM

Target

L. monocytogenes

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM).
Evidence 13 Activity

Activity

MIC
Antiparasitic
34.4 µM

Target

S. lutea

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against par
Evidence 14 Activity

Activity

MIC
Antiparasitic
6.9-8.6 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

against M. luteus (MIC 34.4 uM), L. monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC
Evidence 15 Activity

Activity

MIC
Antiparasitic
17.2-34.4 µM

Target

A. niger

Source & Reference

dbAMP 3.0 DRAMP

Other

monocytogenes (MIC 34.4 uM), S. lutea (MIC 34.4 uM), E. coli (MIC 6.9-8.6 uM) and fungus A. niger (MIC 17.2-34.4 uM). Also active against parasite p. promastigotes (IC50 ~ 100 uM) ( Patiño-Márquez et al., 2
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects. | Biochim Biophys Acta | 2014
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>115 µM
Hemolytic Cytotoxic
50% Hemolysis | >115 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and interactions of cationic peptides derived from Galleria mellonella cecropin D-like peptide with model membranes. | J Antibiot (Tokyo) | 2017
Evidence 18 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 19 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019