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Peptide record

TPDB11820

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB11820
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb dbACP iACP-DRLF Antifungipept i2APP
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP
Physicochemical Analysis
C229H345N69O41
ANDCEQHKMSTWV
P
4720.70
13.00
10
0
9
+10
8.64
-1.308
30.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
31.56
1
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
0
K
0
M
5
F
19
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 0 M: 0 F: 5 P: 19 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
39
C229H345N69O41
4720.70
13.00
+10
8.64
-1.308
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
bacteria B-cereus ATCC 10876 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PA
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

6 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bact
Evidence 3 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

A. Baumannii

Source & Reference

dbAMP DRAMP

Other

3). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5-5.0 µM

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

dbAMP DRAMP

Other

am- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

B. Globigii

Source & Reference

dbAMP DRAMP

Other

eruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 6 Activity

Activity

MIC
Antibacterial
10 µM

Target

L. Monocytogenes

Source & Reference

dbAMP DRAMP

Other

(MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
bacteria B-cereus ATCC 10876 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PA
Evidence 8 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

6 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bact
Evidence 9 Activity

Activity

MIC
Antifungal
2.5 µM

Target

A. Baumannii

Source & Reference

dbAMP DRAMP Antifungipept

Other

3). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40
Evidence 10 Activity

Activity

MIC
Antifungal
2.5-5.0 µM

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

dbAMP DRAMP Antifungipept

Other

am- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes
Evidence 11 Activity

Activity

MIC
Antifungal
5 µM

Target

B. Globigii

Source & Reference

dbAMP DRAMP Antifungipept

Other

eruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 12 Activity

Activity

MIC
Antifungal
10 µM

Target

L. Monocytogenes

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 13 Activity

Activity

MIC
Antiparasitic
10 µM

Target

S. typhimurium

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
bacteria B-cereus ATCC 10876 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PA
Evidence 14 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

6 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bact
Evidence 15 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

A. Baumannii

Source & Reference

DRAMP

Other

3). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40
Evidence 16 Activity

Activity

MIC
Antiparasitic
2.5-5.0 µM

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

DRAMP

Other

am- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes
Evidence 17 Activity

Activity

MIC
Antiparasitic
5 µM

Target

B. Globigii

Source & Reference

DRAMP

Other

eruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 18 Activity

Activity

MIC
Antiparasitic
10 µM

Target

L. Monocytogenes

Source & Reference

DRAMP

Other

(MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 19 Activity

Activity

MIC
Antiviral
10 µM

Target

S. typhimurium

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
bacteria B-cereus ATCC 10876 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PA
Evidence 20 Activity

Activity

MIC
Antiviral
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

6 (MIC >32 ug/ml) (PMID:30641213). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bact
Evidence 21 Activity

Activity

MIC
Antiviral
2.5 µM

Target

A. Baumannii

Source & Reference

DRAMP

Other

3). Also: active against Gram- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40
Evidence 22 Activity

Activity

MIC
Antiviral
2.5-5.0 µM

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1

Source & Reference

DRAMP

Other

am- S. typhimurium (MIC 10 uM), E. coli ATCC 25922 (MIC 5 uM), A. Baumannii (MIC 2.5 uM), P. aeruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes
Evidence 23 Activity

Activity

MIC
Antiviral
5 µM

Target

B. Globigii

Source & Reference

DRAMP

Other

eruginosa ATCC 27853 or PAO1 (MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 24 Activity

Activity

MIC
Antiviral
10 µM

Target

L. Monocytogenes

Source & Reference

DRAMP

Other

(MIC 2.5-5.0 uM), Gram+ bacteria S-aureus MRSA (MIC >40 uM), B. Globigii (MIC 5 uM), and L. Monocytogenes (MIC 10 uM) ( Pashaie et al., 2025 ).
Evidence 25 Activity

Activity

LC50
Toxicity
64 µg/mL
Cytotoxic
LC50 | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Copy number variation of PR-39 cathelicidin, and identification of PR-35, a natural variant of PR-39 with reduced mammalian cytotoxicity. | Gene | 2019