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Peptide record

TPDB11815

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

39 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11815

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0

Sequence_Type

standard

Has_Modification No

Description A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT

FASTA

>TPDB11815|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=39
GLFTLIKGAAKLIGKTVPKKQARLGMNLWLVKLPTNVKT

Formula C198H341N53O47S1

Absent Amino Acids DCEHSY

Common Amino Acids LK

Mass 4248.27

PI 11.93

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 18

Net Charge +8

Boman Index 2.61

Hydrophobicity 0.192

Aliphatic Index 120.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 129.46

Polar Residues 7

number

Amino Acid Distribution

A: 3 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 7 K: 7 M: 1 F: 1 P: 2 S: 0 T: 4 W: 1 Y: 0 V: 3

Length

Formula

C198H341N53O47S1

Mass

4248.27

11.93

Net Charge

Boman Index

2.61

Hydrophobicity

0.192

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.1 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.1 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

inst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.1 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

inst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.7 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.7 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.1 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

inst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 4.7 ug/ml), B. subtilis (MIC 1.1 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.

Evidence 17 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 18 Activity

Activity

Activity Endpoint (28.6±5.7)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(28.6±5.7)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007