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Peptide record

TPDB11806

Antibacterial Antifungal Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB11806
Antibacterial Antifungal Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP NTxPred2
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, Neurotoxin, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FTCAISCDIKVNGKPCKGSGEKKCSGGWSCKFNVCVKV
Physicochemical Analysis
C172H280N48O50S6
RQHLMY
K
4012.77
8.89
7
2
10
+5
6.12
-0.039
53.68
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5875
146.41
13
Residue Composition
number
1
A
0
R
2
N
1
D
6
C
1
E
0
Q
5
G
0
H
2
I
0
L
7
K
0
M
2
F
1
P
4
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 0 K: 7 M: 0 F: 2 P: 1 S: 4 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
38
C172H280N48O50S6
4012.77
8.89
+5
6.12
-0.039
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-2.5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against C. albicans (MIC 2-2.5 uM), A. niger (MIC 10 uM). NO hemolysis at 10 uM. Updated 5/2015.
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. niger

Source & Reference

dbAMP DRAMP

Other

active against C. albicans (MIC 2-2.5 uM), A. niger (MIC 10 uM). NO hemolysis at 10 uM. Updated 5/2015.
Evidence 3 Activity

Activity

MIC
Antifungal
2-2.5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
active against C. albicans (MIC 2-2.5 uM), A. niger (MIC 10 uM). NO hemolysis at 10 uM. Updated 5/2015.
Evidence 4 Activity

Activity

MIC
Antifungal
10 µM

Target

A. niger

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against C. albicans (MIC 2-2.5 uM), A. niger (MIC 10 uM). NO hemolysis at 10 uM. Updated 5/2015.
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Juruin: an antifungal peptide from the venom of the Amazonian Pink Toe spider, Avicularia juruensis, which contains the inhibitory cystine knot motif. | Front Microbiol | 2012
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref. 22973266] It has no hemolytic activity at 10µM against human human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Front. Microbiol. 2012 Sep 3:324-324.