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Peptide record

TPDB11804

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

38 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11804

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GYHGGHGGHGGGYNGGGGHGGHGGGYNGGGHHGGGGHG

FASTA

>TPDB11804|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=38
GYHGGHGGHGGGYNGGGGHGGHGGGYNGGGHHGGGGHG

Formula C133H172N56O44

Absent Amino Acids ARDCEQILKMFPSTWV

Common Amino Acids G

Mass 3259.18

PI 8.12

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 5.95

Hydrophobicity -1.224

Aliphatic Index 0.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4470

Absorbance 280nm 137.15

Polar Residues 5

number

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 25 H: 8 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 3 V: 0

Length

Formula

C133H172N56O44

Mass

3259.18

8.12

Net Charge

Boman Index

5.95

Hydrophobicity

-1.224

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism E. herbicola

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml)

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.mutans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml)

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 60 µg/mL

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism A.fumigatus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

gi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 68 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

eoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism E. herbicola

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml)

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.mutans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 60 µg/mL

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

tans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism A.fumigatus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

gi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 68 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

eoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism E. herbicola

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml)

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.mutans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 60 µg/mL

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

tans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism A.fumigatus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

gi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 68 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

eoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism E. herbicola

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi

Evidence 29 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml)

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against Gram- E. herbicola (IC50 25 ug/ml), E. coli (IC50 100 ug/ml), S.aureus (IC50 >100 ug/ml), S.mutans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug

Evidence 31 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism S.mutans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 5 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 33 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 100 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 34 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 60 µg/mL

Target

Target Organism A. flavus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

tans (IC50 >100 ug/ml), fungi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 35 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µg/mL

Target

Target Organism A.fumigatus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

gi C. albicans (IC50 5 ug/ml), C. neoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).

Evidence 36 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 68 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

eoformans (IC50 100 ug/ml), A. flavus (IC50 60 ug/ml), A.fumigatus (IC50 >100 ug/ml), and F. culmorum (IC50 68 ug/ml).