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Peptide record

TPDB11798

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11798
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb AFP-GFuse Antifungipept CAFPdb DRAVP 2.0
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Physicochemical Analysis
C197H338N56O50
DCHMTWY
K
4291.20
10.97
10
3
13
+7
12.44
-0.582
102.63
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
3
E
3
Q
5
G
0
H
4
I
5
L
8
K
0
M
2
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 3 Q: 3 G: 5 H: 0 I: 4 L: 5 K: 8 M: 0 F: 2 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
38
C197H338N56O50
4291.20
10.97
+7
12.44
-0.582
Evidence Records 33 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-2 µM

Target

Escherichia coli ATCC 25922 or ML35 or D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

t E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP

Other

MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

s ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

C 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM)
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

4 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is esse
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

is ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is essentially the same as a hypothetically alternatively cleaved
Evidence 9 Activity

Activity

MIC
Antifungal
0.5-2 µM

Target

Escherichia coli ATCC 25922 or ML35 or D21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or
Evidence 13 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM)
Evidence 15 Activity

Activity

MIC
Antifungal
4 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

4 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is esse
Evidence 16 Activity

Activity

MIC
Antifungal
16 µM

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

is ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is essentially the same as a hypothetically alternatively cleaved
Evidence 17 Activity

Activity

MIC
Antiparasitic
0.5-2 µM

Target

Escherichia coli ATCC 25922 or ML35 or D21

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC
Evidence 19 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

t E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25
Evidence 20 Activity

Activity

MIC
Antiparasitic
4 µM

Target

S. marcescens ATCC 8100

Source & Reference

DRAMP

Other

MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or
Evidence 21 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

DRAMP

Other

s ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC
Evidence 22 Activity

Activity

MIC
Antiparasitic
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

DRAMP

Other

C 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM)
Evidence 23 Activity

Activity

MIC
Antiparasitic
4 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP

Other

4 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is esse
Evidence 24 Activity

Activity

MIC
Antiparasitic
16 µM

Target

C. neoformans

Source & Reference

DRAMP

Other

is ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is essentially the same as a hypothetically alternatively cleaved
Evidence 25 Activity

Activity

MIC
Antiviral
0.5-2 µM

Target

Escherichia coli ATCC 25922 or ML35 or D21

Source & Reference

DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens
Evidence 26 Activity

Activity

MIC
Antiviral
8 µM

Target

S. typhimurium ATCC 14028

Source & Reference

DRAMP DRAVP 2.0

Other

Active against E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC
Evidence 27 Activity

Activity

MIC
Antiviral
4 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP DRAVP 2.0

Other

t E. coli ATCC 25922 or ML35 or D21 (MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25
Evidence 28 Activity

Activity

MIC
Antiviral
4 µM

Target

S. marcescens ATCC 8100

Source & Reference

DRAMP DRAVP 2.0

Other

MIC 0.5-2 uM), S. typhimurium ATCC 14028 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 4 uM), S. marcescens ATCC 8100 (MIC 4 uM), P-vulgaris ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or
Evidence 29 Activity

Activity

MIC
Antiviral
16 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

DRAMP DRAVP 2.0

Other

s ATCC 13315 (MIC>64 uM), S. aureus ATCC 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC
Evidence 30 Activity

Activity

MIC
Antiviral
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

DRAMP DRAVP 2.0

Other

C 25923 or Cowan I or MRSA (MIC 32-64 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM)
Evidence 31 Activity

Activity

MIC
Antiviral
4 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP DRAVP 2.0

Other

4 or greater), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is esse
Evidence 32 Activity

Activity

MIC
Antiviral
16 µM

Target

C. neoformans

Source & Reference

DRAMP DRAVP 2.0

Other

is ATCC 29212 (MIC 16 uM), B. megaterium Bm11 (MIC 4 uM), fumgi C-albicans (MIC > 64 uM), C. neoformans (MIC 16 uM). The activity spectrum is essentially the same as a hypothetically alternatively cleaved
Evidence 33 Activity

Activity

2% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity | Biochem Biophys Res Commun | 2000