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Peptide record

TPDB11783

Antibacterial Antifungal standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB11783
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 38-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VAKCTEESGGKYFVFCCYKPTRICYMNEQKCESTCIGK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C187H292N48O57S7
DHLW
C
4349.08
8.01
6
4
11
+2
1.54
-0.361
38.42
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
4845
1.11
16
Residue Composition
number
1
A
1
R
1
N
0
D
6
C
4
E
1
Q
3
G
0
H
2
I
0
L
5
K
1
M
2
F
1
P
2
S
3
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 6 E: 4 Q: 1 G: 3 H: 0 I: 2 L: 0 K: 5 M: 1 F: 2 P: 1 S: 2 T: 3 W: 0 Y: 3 V: 2
Chemical Descriptors
38 reviewed residue count
C187H292N48O57S7 sequence-only estimate (linear, free termini)
4349.08 sequence-only estimate (linear, free termini)
8.01 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.54 sequence-only estimate (linear, free termini)
-0.361 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Antibacterial
5.8 µM

Target

B. cinerea

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
subtilis (1.0-1.2 cm) loaded 30 ul at 6 ug/ul (180 ug peptide). Also active against fungi B. cinerea (IC50 5.8 uM), A. niger (IC50 5.6 uM), but no activity below 10 uM against F-oxysporum, F-graminearum,
Evidence 2 Activity

Activity

IC50
Antibacterial
5.6 µM

Target

A. niger

Source & Reference

dbAMP DRAMP

Other

ed 30 ul at 6 ug/ul (180 ug peptide). Also active against fungi B. cinerea (IC50 5.8 uM), A. niger (IC50 5.6 uM), but no activity below 10 uM against F-oxysporum, F-graminearum, B-sorokiniana, and P-deb
Evidence 3 Activity

Activity

IC50
Antifungal
5.8 µM

Target

B. cinerea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
subtilis (1.0-1.2 cm) loaded 30 ul at 6 ug/ul (180 ug peptide). Also active against fungi B. cinerea (IC50 5.8 uM), A. niger (IC50 5.6 uM), but no activity below 10 uM against F-oxysporum, F-graminearum,
Evidence 4 Activity

Activity

IC50
Antifungal
5.6 µM

Target

A. niger

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ed 30 ul at 6 ug/ul (180 ug peptide). Also active against fungi B. cinerea (IC50 5.8 uM), A. niger (IC50 5.6 uM), but no activity below 10 uM against F-oxysporum, F-graminearum, B-sorokiniana, and P-deb