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Peptide record

TPDB11780

Antibacterial Antifungal Hemolysis Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11780
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFGCPFNENECHAHCLSIGRKFGFCAGPLRATCTCGKQ
Physicochemical Analysis
C173H263N53O49S6
DMWYV
CG
4061.68
8.03
6
2
10
+2
4.45
-0.126
38.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
9.23
12
Residue Composition
number
3
A
2
R
2
N
0
D
6
C
2
E
1
Q
6
G
2
H
1
I
2
L
2
K
0
M
4
F
2
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 0 C: 6 E: 2 Q: 1 G: 6 H: 2 I: 1 L: 2 K: 2 M: 0 F: 4 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
38
C173H263N53O49S6
4061.68
8.03
+2
4.45
-0.126
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
us and Gram-negative bacteria P. aeruginosa and A. tumefaciens. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102
Evidence 2 Activity

Activity

MIC
Antibacterial
>64 µM

Target

B.cereus BNCC 103930

Source & Reference

dbAMP

Other

. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis AT
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. subtilis BNCC 109047

Source & Reference

dbAMP

Other

us BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis cli
Evidence 4 Activity

Activity

MIC
Antibacterial
>64 µM

Target

M.luteus BNCC 102589

Source & Reference

dbAMP

Other

C 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

3930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739
Evidence 6 Activity

Activity

MIC
Antibacterial
>64 µM

Target

Enterococcus faecalis clinical

Source & Reference

dbAMP

Other

047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens AT
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

E. faecium

Source & Reference

dbAMP

Other

89 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (
Evidence 8 Activity

Activity

MIC
Antibacterial
>64 µM

Target

S.marcescens ATCC 14756

Source & Reference

dbAMP

Other

al (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (ref see AP5784).
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
us and Gram-negative bacteria P. aeruginosa and A. tumefaciens. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102
Evidence 10 Activity

Activity

MIC
Antifungal
>64 µM

Target

B.cereus BNCC 103930

Source & Reference

dbAMP Antifungipept

Other

. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis AT
Evidence 11 Activity

Activity

MIC
Antifungal
2 µM

Target

B. subtilis BNCC 109047

Source & Reference

dbAMP Antifungipept

Other

us BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis cli
Evidence 12 Activity

Activity

MIC
Antifungal
>64 µM

Target

M.luteus BNCC 102589

Source & Reference

dbAMP Antifungipept

Other

C 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC
Evidence 13 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP Antifungipept

Other

3930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739
Evidence 14 Activity

Activity

MIC
Antifungal
>64 µM

Target

Enterococcus faecalis clinical

Source & Reference

dbAMP Antifungipept

Other

047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens AT
Evidence 15 Activity

Activity

MIC
Antifungal
2 µM

Target

E. faecium

Source & Reference

dbAMP Antifungipept

Other

89 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (
Evidence 16 Activity

Activity

MIC
Antifungal
>64 µM

Target

S.marcescens ATCC 14756

Source & Reference

dbAMP Antifungipept

Other

al (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (ref see AP5784).
Evidence 17 Activity

Activity

20% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
20% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Dermatophytic defensin with antiinfective potential. | Proc Natl Acad Sci U S A | 2012
Evidence 18 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. | FASEB J | 2016
Evidence 19 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.