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Peptide record

TPDB11780

Antibacterial Antifungal Hemolysis Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB11780
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 38-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFGCPFNENECHAHCLSIGRKFGFCAGPLRATCTCGKQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C173H263N53O49S6
DMWYV
CG
4061.68
8.03
6
2
10
+2
1.21
-0.126
38.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
0.09
12
Residue Composition
number
3
A
2
R
2
N
0
D
6
C
2
E
1
Q
6
G
2
H
1
I
2
L
2
K
0
M
4
F
2
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 0 C: 6 E: 2 Q: 1 G: 6 H: 2 I: 1 L: 2 K: 2 M: 0 F: 4 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
38 reviewed residue count
C173H263N53O49S6 sequence-only estimate (linear, free termini)
4061.68 sequence-only estimate (linear, free termini)
8.03 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.21 sequence-only estimate (linear, free termini)
-0.126 sequence-only estimate (linear, free termini)
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
us and Gram-negative bacteria P. aeruginosa and A. tumefaciens. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102
Evidence 2 Activity

Activity

MIC
Antibacterial
>64 µM

Target

B.cereus BNCC 103930

Source & Reference

dbAMP

Other

. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis AT
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

B. subtilis BNCC 109047

Source & Reference

dbAMP

Other

us BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis cli
Evidence 4 Activity

Activity

MIC
Antibacterial
>64 µM

Target

M.luteus BNCC 102589

Source & Reference

dbAMP

Other

C 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

3930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739
Evidence 6 Activity

Activity

MIC
Antibacterial
>64 µM

Target

Enterococcus faecalis clinical

Source & Reference

dbAMP

Other

047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens AT
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

E. faecium

Source & Reference

dbAMP

Other

89 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (
Evidence 8 Activity

Activity

MIC
Antibacterial
>64 µM

Target

S.marcescens ATCC 14756

Source & Reference

dbAMP

Other

al (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (ref see AP5784).
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
us and Gram-negative bacteria P. aeruginosa and A. tumefaciens. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102
Evidence 10 Activity

Activity

MIC
Antifungal
>64 µM

Target

B.cereus BNCC 103930

Source & Reference

dbAMP Antifungipept

Other

. Also active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis AT
Evidence 11 Activity

Activity

MIC
Antifungal
2 µM

Target

B. subtilis BNCC 109047

Source & Reference

dbAMP Antifungipept

Other

us BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis cli
Evidence 12 Activity

Activity

MIC
Antifungal
>64 µM

Target

M.luteus BNCC 102589

Source & Reference

dbAMP Antifungipept

Other

C 6538 (MIC 4 uM), B.cereus BNCC 103930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC
Evidence 13 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP Antifungipept

Other

3930 (MIC >64 uM), B. subtilis BNCC 109047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739
Evidence 14 Activity

Activity

MIC
Antifungal
>64 µM

Target

Enterococcus faecalis clinical

Source & Reference

dbAMP Antifungipept

Other

047 (MIC 2 uM), M.luteus BNCC 102589 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens AT
Evidence 15 Activity

Activity

MIC
Antifungal
2 µM

Target

E. faecium

Source & Reference

dbAMP Antifungipept

Other

89 (MIC >64 uM), S. epidermidis ATCC 12228 (MIC 32 uM), E.faecalis clinical (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (
Evidence 16 Activity

Activity

MIC
Antifungal
>64 µM

Target

S.marcescens ATCC 14756

Source & Reference

dbAMP Antifungipept

Other

al (MIC >64 uM), E. faecium (MIC 2 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM) (ref see AP5784).
Evidence 17 Activity

Activity

20% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
20% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Dermatophytic defensin with antiinfective potential. | Proc Natl Acad Sci U S A | 2012
Evidence 18 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin. | FASEB J | 2016
Evidence 19 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.