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Peptide record

TPDB11779

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

38 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB11779

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLSGILGAGKHIVCGLSGPCQSLNRKSSDVEYHLAKC

FASTA

>TPDB11779|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=38
GLLSGILGAGKHIVCGLSGPCQSLNRKSSDVEYHLAKC

Formula C168H280N50O51S3

Absent Amino Acids MFTW

Common Amino Acids GL

Mass 3912.56

PI 8.55

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +2

Boman Index 5.27

Hydrophobicity 0.142

Aliphatic Index 102.63

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 41.28

Polar Residues 11

number

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 1 C: 3 E: 1 Q: 1 G: 6 H: 2 I: 2 L: 6 K: 3 M: 0 F: 0 P: 1 S: 5 T: 0 W: 0 Y: 1 V: 2

Length

Formula

C168H280N50O51S3

Mass

3912.56

8.55

Net Charge

Boman Index

5.27

Hydrophobicity

0.142

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nst E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml)

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml)

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

nst E. coli (MIC 6.3 ug/ml), S. aureus (MIC 3.1 ug/ml), B. subtilis (MIC 12.5 ug/ml), and C. albicans (MIC 3.1 ug/ml). Aslo histamine release.

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 14 Activity

Activity

Activity Endpoint (12.5±5.6)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(12.5±5.6)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:17272268]Non-hemolytic activity against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.