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Peptide record

TPDB11778

Antibacterial Antifungal Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB11778
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 38-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVKG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C185H316N56O46
CHLMSY
V
4060.89
11.62
9
2
18
+7
1.09
0.082
107.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
1.35
3
Residue Composition
number
5
A
3
R
1
N
1
D
0
C
1
E
1
Q
5
G
0
H
4
I
0
L
6
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
7
V
Amino Acid Distribution
A: 5 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 5 H: 0 I: 4 L: 0 K: 6 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 7
Chemical Descriptors
38 reviewed residue count
C185H316N56O46 sequence-only estimate (linear, free termini)
4060.89 sequence-only estimate (linear, free termini)
11.62 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
1.09 sequence-only estimate (linear, free termini)
0.082 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization and cDNA cloning of a cecropin-like antimicrobial peptide, papiliocin, from the swallowtail butterfly, Papilio xuthus. | Mol Cells | 2010